{"id":"W1964955754","doi":"10.1073/pnas.181479798","title":"Specificity in intracellular protein aggregation and inclusion body formation","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Golder Associates (Canada)","funders":"National Institutes of Health","keywords":"Protein aggregation; Förster resonance energy transfer; Protein folding; Biophysics; Chemistry; Aggresome; Protein structure; Cell biology; Biochemistry; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007086794,0.00007085936,0.00008456408,0.0001800942,0.0003861452,0.00002179748,0.0004076396,0.00003725307,0.00000691874],"category_scores_gemma":[0.001206742,0.00005101083,0.00002296454,0.0007916558,0.0004778314,0.0006170888,0.0005913983,0.00009410716,6.100246e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002793629,"about_ca_system_score_gemma":0.00001520092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000030068,"about_ca_topic_score_gemma":1.233298e-7,"domain_scores_codex":[0.998401,0.00001978086,0.0002676141,0.0002292641,0.0009730383,0.0001092564],"domain_scores_gemma":[0.99951,0.00006592809,0.0002929021,0.000006283433,0.00009977484,0.00002512063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001440901,0.00004110019,0.002644741,0.00002238656,2.608674e-7,1.114601e-8,0.0002436082,0.00008739813,0.9785721,0.0177187,0.00001398294,0.0006413234],"study_design_scores_gemma":[0.0001218339,0.00002892636,0.02674921,0.00005690495,0.000001501307,0.000005835549,0.00004562338,0.004832598,0.9104949,0.05757042,0.00004499133,0.00004722336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960957,0.00004549652,0.000005103109,0.001981393,0.000007707255,0.0003303945,0.00000427422,0.000006836852,0.001523138],"genre_scores_gemma":[0.9994153,0.00004865666,0.000285358,0.0001699974,0.00002488055,0.00001193379,5.359781e-8,0.000002396656,0.00004142068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06807715,"threshold_uncertainty_score":0.2969956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04362187695938212,"score_gpt":0.2906197839133996,"score_spread":0.2469979069540175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}