{"id":"W1964955754","doi":"10.1073/pnas.181479798","title":"Specificity in intracellular protein aggregation and inclusion body formation","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Golder Associates (Canada)","funders":"National Institutes of Health","keywords":"Protein aggregation; Förster resonance energy transfer; Protein folding; Biophysics; Chemistry; Aggresome; Protein structure; Cell biology; Biochemistry; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005938717,0.0002550893,0.0005234213,0.0001913063,0.0002560843,0.0005877505,0.0002642152,0.0004991816,0.0004943348],"category_scores_gemma":[0.0009761834,0.0001942954,0.0002019522,0.0001477271,0.0006178842,0.0004581334,0.0005107769,0.0006032329,0.0004161607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003068513,"about_ca_system_score_gemma":0.000199491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000400207,"about_ca_topic_score_gemma":0.0003746935,"domain_scores_codex":[0.9991361,0.0001558398,0.00006308206,0.0002280541,0.0002923159,0.0001246149],"domain_scores_gemma":[0.9993619,0.0001981864,0.0001216623,0.0001310563,0.0001255677,0.00006162963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000456597,0.000005881332,0.0002754257,0.00002366563,0.00000315237,0.00003575657,0.0000258845,0.00005941159,0.9984512,0.0002027079,0.00001776644,0.0008534635],"study_design_scores_gemma":[0.000002642381,0.00003966549,0.002560508,0.000003473645,0.000005168278,0.0004219149,0.00001711362,0.0008154963,0.9952666,0.0001404424,0.0007224536,0.000004484252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748878,0.002040965,0.02080116,0.00009180871,0.00001701744,0.00002465045,0.0001006722,0.0001171947,0.001918891],"genre_scores_gemma":[0.9944831,0.0004515981,0.004078542,0.00006448454,0.000004370082,0.00002226593,0.0001159561,0.0000292482,0.0007504714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005938717,"threshold_uncertainty_score":0.003140748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04362187695938212,"score_gpt":0.2906197839133996,"score_spread":0.2469979069540175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}