{"id":"W1964982955","doi":"10.4161/pri.2.1.6280","title":"Susceptibility of cell substrates to PrP<sup>Sc</sup>infection and safety control measures related to biological and biotherapeutical products","year":2008,"lang":"en","type":"review","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Ottawa; Health Canada","funders":"","keywords":"Infectious agent; Asymptomatic; Prion Proteins; Prion protein; Virology; Biology; Disease; Transmission (telecommunications); Medicine; Immunology; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007762386,0.0007828097,0.001311993,0.001672862,0.0003112012,0.00107364,0.0008596433,0.001346607,0.001902829],"category_scores_gemma":[0.0008479082,0.0002705516,0.000320938,0.001591881,0.0007595978,0.001232494,0.0004661662,0.0009732943,0.002606383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000550656,"about_ca_system_score_gemma":0.0005456809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000731942,"about_ca_topic_score_gemma":0.000901912,"domain_scores_codex":[0.9997268,0.00004558176,0.0000286315,0.00004742802,0.0001354205,0.00001615101],"domain_scores_gemma":[0.9995189,0.0002520768,0.00006302347,0.00002594972,0.0001150072,0.00002511179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006464539,0.00006968913,0.0002717642,0.008564012,0.00003015501,0.0005384941,0.00008778886,0.0005437355,0.01560616,0.004762792,0.009605043,0.9598557],"study_design_scores_gemma":[0.0000157058,0.0002354847,0.001896193,0.001849483,0.00006388079,0.004701812,0.0001448536,0.0002274179,0.01184861,0.003822834,0.975159,0.00003472946],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006539185,0.9949046,0.0007590545,0.0002099855,0.0001764107,0.000007435947,0.0000124718,0.00001593019,0.003260072],"genre_scores_gemma":[0.003066149,0.9924108,0.00117414,0.0001822889,0.0001495531,0.00001685691,0.00002795976,0.000003983564,0.002968348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001902829,"threshold_uncertainty_score":0.006365538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02945752054293345,"score_gpt":0.2969085293746472,"score_spread":0.2674510088317138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}