{"id":"W1964996667","doi":"10.1021/cc050002l","title":"Deazapurine Solid-Phase Synthesis:  Construction of 3-Substituted Pyrrolo[3,2-<i>d</i>]pyrimidine-6-carboxylates on Cross-Linked Polystyrene Bearing a Cysteamine Linker","year":2005,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Multicomponent Synthesis of Heterocycles","field":"Chemistry","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Acylation; Pyrimidine; Linker; Polystyrene; Solid-phase synthesis; Sulfone; Alkyl; Sulfur; Aryl; Cysteamine; Residue (chemistry); Polymer chemistry; Thiophene; Medicinal chemistry; Organic chemistry; Stereochemistry; Catalysis; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005580684,0.0005573381,0.001181862,0.0001688472,0.0001564539,0.0001001079,0.0007909692,0.000556917,0.0006257234],"category_scores_gemma":[0.001030489,0.0005338259,0.0005624347,0.0001257676,0.0003470124,0.0004222245,0.0001285382,0.0009046472,0.00001267335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003461478,"about_ca_system_score_gemma":0.0001740094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000151523,"about_ca_topic_score_gemma":5.389278e-7,"domain_scores_codex":[0.9958913,0.00005533833,0.002067696,0.0004244086,0.001019513,0.0005417098],"domain_scores_gemma":[0.9957168,0.0006492242,0.002116715,0.0006604563,0.0004869607,0.0003699067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002462433,0.00149114,0.001258512,0.0005218124,0.0004514106,0.00006381436,0.00005956391,0.0006186169,0.9905293,0.0000878471,0.00003820143,0.002417363],"study_design_scores_gemma":[0.007342803,0.00005896922,0.0002228783,0.0009406615,0.0002770403,0.0003179532,0.00006753529,0.0005957482,0.9886028,0.0004202723,0.0007069419,0.0004463973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968513,0.0004399995,0.00002290693,0.0002613227,0.0008971867,0.00008729449,0.00003894433,0.00008796996,0.001313109],"genre_scores_gemma":[0.9957736,0.0001094174,0.001268555,0.00001049858,0.002691908,0.00001132799,0.0000151165,0.00007995715,0.00003963405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00488037,"threshold_uncertainty_score":0.9997113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507817949143692,"score_gpt":0.2994020793629179,"score_spread":0.2843238998714809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}