{"id":"W1965044238","doi":"10.1021/bi7018173","title":"Core Residue Replacements Cause Coiled-Coil Orientation Switching<i>in Vitro</i>and<i>in Vivo</i>:  Structure−Function Correlations for Osmosensory Transporter ProP","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Antiparallel (mathematics); Coiled coil; Heptad repeat; Biophysics; Mutant; Chemistry; Transmembrane domain; Biochemistry; Crystallography; Peptide sequence; Biology; Amino acid; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385257,0.0002106527,0.0001718219,0.00007549508,0.00007047232,0.00001748547,0.000107441,0.0005391493,0.00001263599],"category_scores_gemma":[0.00006270914,0.0002185721,0.00005240458,0.0001349375,0.00007022981,0.000005552815,0.00003592037,0.0001665689,6.110178e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004079281,"about_ca_system_score_gemma":0.00007110213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002967281,"about_ca_topic_score_gemma":0.0003372617,"domain_scores_codex":[0.998579,0.00001340991,0.0004122087,0.0005567036,0.0001057159,0.0003329488],"domain_scores_gemma":[0.9993898,0.00001739507,0.0001394331,0.0003144246,0.00006922843,0.00006976696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001551284,0.00006573343,0.007400019,0.00005870463,0.00002328579,0.000005482325,0.00004265739,0.00001110196,0.9896585,0.00001550878,0.0001842529,0.0009834639],"study_design_scores_gemma":[0.001642659,0.0001414216,0.008712779,0.00002843548,0.00002886458,0.00001998189,0.00009956049,0.00006736821,0.9868127,0.0001243266,0.002072495,0.0002494119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972016,0.0001770391,0.001603489,0.00008628838,0.0002534928,0.0004196304,0.0001411147,0.0000181312,0.00009922012],"genre_scores_gemma":[0.9971161,0.00005450198,0.001324004,0.0001479341,0.0002094509,0.00003322895,0.0006362573,0.00002795382,0.0004505068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002845809,"threshold_uncertainty_score":0.891311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01338121113736295,"score_gpt":0.25485230503907,"score_spread":0.241471093901707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}