{"id":"W1965064177","doi":"10.1074/jbc.m604958200","title":"Contribution of Interferon-β to the Murine Macrophage Response to the Toll-like Receptor 4 Agonist, Lipopolysaccharide","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Lipopolysaccharide; Toll-like receptor; Agonist; Macrophage; Interferon; Receptor; Chemistry; Immunology; Innate immune system; Medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001525386,0.0001443227,0.0002991498,0.00003778122,0.0001494527,0.000018382,0.0004918279,0.0002350573,0.0005205667],"category_scores_gemma":[0.0009799491,0.00006953938,0.0001875099,0.0001245503,0.0001416967,0.0000379637,0.0001316573,0.0003998926,0.000141048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008149115,"about_ca_system_score_gemma":0.00006186201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001881387,"about_ca_topic_score_gemma":0.000002407681,"domain_scores_codex":[0.9984959,0.0003853367,0.0006755482,0.0001318321,0.00006446082,0.0002468585],"domain_scores_gemma":[0.9986486,0.0004231953,0.0003887906,0.0002536306,0.000255982,0.00002984607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009462015,0.00007086252,0.0001133597,0.000004294132,0.00005580304,0.000006377035,0.00006258686,0.00003182576,0.9765059,0.00002688233,0.01275745,0.0009026698],"study_design_scores_gemma":[0.0004912142,0.0005143118,0.002367234,0.00003656881,0.00001737553,0.0001837808,0.0001308849,8.579348e-7,0.8317504,0.00002465038,0.1644073,0.00007542982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892445,0.001408036,0.0004036051,0.008223115,0.0004222386,0.0001579219,0.00002520344,0.00001089585,0.0001044687],"genre_scores_gemma":[0.9976567,0.00005269626,0.00004122836,0.000327054,0.0002250958,0.000008716778,0.00002392804,0.000005542387,0.001659012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1516498,"threshold_uncertainty_score":0.569984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008700375731794401,"score_gpt":0.2333411432891601,"score_spread":0.2246407675573657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}