{"id":"W1965094267","doi":"10.1053/j.ajkd.2014.08.009","title":"Surrogate Outcomes for ESRD Risk: The Case for a 30% Reduction in Estimated GFR Over 2 Years","year":2014,"lang":"en","type":"letter","venue":"American Journal of Kidney Diseases","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"","keywords":"Medicine; Surrogate endpoint; Renal function; Reduction (mathematics); Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00773906,0.0005849256,0.00225504,0.0005617515,0.002080095,0.002422139,0.001301456,0.03427401,0.003537622],"category_scores_gemma":[0.05591491,0.0005054852,0.001538249,0.0006276694,0.002203807,0.003295436,0.001311502,0.0351799,0.001957012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003155573,"about_ca_system_score_gemma":0.003949023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004824499,"about_ca_topic_score_gemma":0.007891929,"domain_scores_codex":[0.9924594,0.004058432,0.001105567,0.0005011008,0.001395863,0.0004796492],"domain_scores_gemma":[0.9700089,0.02216244,0.00192934,0.0008267932,0.002895231,0.002177195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004155322,0.0001503612,0.01341014,0.000129743,0.00008961755,0.006440002,0.0002837973,0.0003667027,0.0003099019,0.01106796,0.9156508,0.05168539],"study_design_scores_gemma":[0.0009617932,0.000694669,0.01954346,0.002357993,0.0003109224,0.02758601,0.001493247,0.004819556,0.0007346534,0.0820002,0.8591785,0.0003190758],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001032662,0.001026242,0.000229186,0.990776,0.004745275,0.000006016295,0.00006487444,0.00001414949,0.00210553],"genre_scores_gemma":[0.02343822,0.001896385,0.001733977,0.9265927,0.04328967,0.00006829112,0.0001010585,0.00002971334,0.002849871],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03427401,"threshold_uncertainty_score":0.0409286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168891701364791,"score_gpt":0.3091721578668042,"score_spread":0.2922829877303251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}