{"id":"W1965097080","doi":"10.1158/1535-7163.mct-04-0297","title":"Raf kinase as a target for anticancer therapeutics","year":2005,"lang":"en","type":"review","venue":"Molecular Cancer Therapeutics","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"MAPK/ERK pathway; Receptor tyrosine kinase; Kinase; Tyrosine kinase; Cancer research; Signal transduction; Biology; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002438564,0.0009561764,0.001355752,0.0001316389,0.0001577323,0.00008960727,0.0008062453,0.0009875401,0.00009547202],"category_scores_gemma":[0.00001609642,0.0008477849,0.001179758,0.000233423,0.0001526902,0.0000051411,0.000169137,0.0003743115,0.00004813408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001334101,"about_ca_system_score_gemma":0.001217433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001452974,"about_ca_topic_score_gemma":0.00001666475,"domain_scores_codex":[0.9968376,0.0001966337,0.0007067025,0.001068449,0.0003483076,0.0008423753],"domain_scores_gemma":[0.9979401,0.00004011383,0.0004366282,0.001188524,0.0002103047,0.0001843711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008206576,0.0001249569,0.000002060134,0.002014153,0.001622101,0.0000197067,0.00003281175,0.00001564992,0.009118518,0.0004482844,0.0005853756,0.9859343],"study_design_scores_gemma":[0.000737434,0.0004952103,2.812855e-7,0.0008215375,0.0019751,0.00003573781,0.000008819394,0.00002561212,0.01127334,0.0001771456,0.9834293,0.001020541],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007692914,0.9884716,0.007155266,0.0001573336,0.000799529,0.001842508,0.000568069,0.00005086054,0.0008778781],"genre_scores_gemma":[0.0001400288,0.9881042,0.002350841,0.003487072,0.00145849,0.001297398,0.0008823769,0.0003541313,0.001925444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9849138,"threshold_uncertainty_score":0.9993973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05591067051033215,"score_gpt":0.3620443422933081,"score_spread":0.3061336717829759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}