{"id":"W1965099195","doi":"10.1016/j.semcancer.2015.03.007","title":"Therapeutic targeting of replicative immortality","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Ikerbasque, Basque Foundation for Science; W. W. Smith Charitable Trust; University of New South Wales; Ministero della Salute; National Institute of Environmental Health Sciences; Verein fur Krebsforschung; University of Glasgow; Cancer Research UK; Ministry of Education, Culture, Sports, Science and Technology; California Breast Cancer Research Program; National Institutes of Health; Terry Fox Foundation; Kate Verdon Spisak Foundation for Melanoma Awareness and Research; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Senescence; Biology; Telomerase; Cancer research; DNA damage; Cancer; Cancer cell; Telomere; Cell biology; Cell cycle; Genome instability; DNA repair; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003970632,0.0005435756,0.0004933315,0.0005952073,0.0002051929,0.0006718474,0.0004778892,0.0005391345,0.00318879],"category_scores_gemma":[0.0002715745,0.0001428268,0.0004938088,0.0002415502,0.000331703,0.000412854,0.0004511885,0.001873713,0.000813836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004104232,"about_ca_system_score_gemma":0.0003549933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002376754,"about_ca_topic_score_gemma":0.0005050034,"domain_scores_codex":[0.9998357,0.00003500113,0.000007980477,0.00002614363,0.00005085994,0.00004416547],"domain_scores_gemma":[0.9998893,0.00002366367,0.00002858988,0.00001911487,0.0000165374,0.00002273886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007521347,0.0008278904,0.0006690862,0.001397651,0.0001707769,0.0004939158,0.0001249932,0.001704724,0.755277,0.0164132,0.007934904,0.2142336],"study_design_scores_gemma":[0.0005451509,0.006255959,0.005057609,0.000390379,0.000425899,0.003766587,0.0001388308,0.00696234,0.5626577,0.009247145,0.4044914,0.00006099482],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5325868,0.2180728,0.1441836,0.007131628,0.002691357,0.00130362,0.00216518,0.002924272,0.08894089],"genre_scores_gemma":[0.9165161,0.05602521,0.01318991,0.001286271,0.0003700973,0.0005165983,0.0009667897,0.0001175856,0.01101148],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00318879,"threshold_uncertainty_score":0.01066756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129256444543894,"score_gpt":0.4657893991798987,"score_spread":0.3365329546360047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}