{"id":"W1965099195","doi":"10.1016/j.semcancer.2015.03.007","title":"Therapeutic targeting of replicative immortality","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Ikerbasque, Basque Foundation for Science; W. W. Smith Charitable Trust; University of New South Wales; Ministero della Salute; National Institute of Environmental Health Sciences; Verein fur Krebsforschung; University of Glasgow; Cancer Research UK; Ministry of Education, Culture, Sports, Science and Technology; California Breast Cancer Research Program; National Institutes of Health; Terry Fox Foundation; Kate Verdon Spisak Foundation for Melanoma Awareness and Research; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Senescence; Biology; Telomerase; Cancer research; DNA damage; Cancer; Cancer cell; Telomere; Cell biology; Cell cycle; Genome instability; DNA repair; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007642783,0.0003647768,0.00252604,0.0002236159,0.00002120262,0.000002396244,0.0002803978,0.000540429,0.0001186494],"category_scores_gemma":[0.0001772371,0.0002683315,0.0002745261,0.0005425231,0.0003743428,0.00001999112,0.00009243422,0.0005568163,0.00001207769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003794933,"about_ca_system_score_gemma":0.001031416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004989015,"about_ca_topic_score_gemma":0.00004593542,"domain_scores_codex":[0.9976264,0.0002935506,0.0009097884,0.0006467082,0.0001375397,0.0003860529],"domain_scores_gemma":[0.9982526,0.0002090438,0.0006315764,0.0006410191,0.0001581195,0.0001076688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003931462,0.0000773897,0.00324802,0.005832059,0.0001565197,0.00001679069,0.0002127762,7.796086e-8,0.00007011464,0.0001068992,0.0006935004,0.9895465],"study_design_scores_gemma":[0.0002657236,0.0002810474,0.0001621972,0.01052793,0.00039601,0.00004076688,0.00009620332,0.000001454147,0.00007130059,0.0002100591,0.9876946,0.0002527366],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004397835,0.9971769,0.00000653562,0.00007180782,0.0004085656,0.0007712749,0.0001457989,0.00002796645,0.0009512963],"genre_scores_gemma":[0.0008214531,0.997845,0.0002389114,0.00009971742,0.0002288475,0.0002188441,0.0002469858,0.0000407644,0.0002594548],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9892938,"threshold_uncertainty_score":0.9999769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.129256444543894,"score_gpt":0.4657893991798987,"score_spread":0.3365329546360047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}