{"id":"W1965101167","doi":"10.1002/cbic.201300322","title":"The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above‐Average Backbone Dynamics","year":2013,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Transmembrane domain; Cleavage (geology); Transmembrane protein; Chemistry; Helix (gastropod); Amyloid precursor protein; Molecular dynamics; Dynamics (music); Biophysics; Membrane; Biochemistry; Materials science; Biology; Physics; Computational chemistry; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002379707,0.000314851,0.0002496553,0.00001920935,0.0002295187,0.00006498686,0.0007849736,0.0003208183,0.0000357967],"category_scores_gemma":[0.00008428336,0.0001718517,0.0002622933,0.0001502518,0.000412222,0.00000985861,0.0002238263,0.0002582633,0.00001560789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003586131,"about_ca_system_score_gemma":0.00008945193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004452964,"about_ca_topic_score_gemma":0.000166378,"domain_scores_codex":[0.9983246,0.00007916736,0.0004102221,0.0004532364,0.000286056,0.0004466684],"domain_scores_gemma":[0.9984504,0.00002593787,0.0002226697,0.001068697,0.0001321075,0.0001002068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00012001,0.00004621036,0.00006604545,0.00008851192,0.00006627452,6.887899e-7,0.00008597421,0.000004704886,0.9955143,0.0009517548,0.0004335455,0.002621924],"study_design_scores_gemma":[0.0006376505,0.0001132999,0.0004942707,0.00003934207,0.00001790278,0.000009725471,0.000126997,0.0001460165,0.9927335,0.001751539,0.003662455,0.0002672754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921449,0.0005512307,0.0009053051,0.001488471,0.0001953412,0.00126555,0.0001221159,0.00002209164,0.003304972],"genre_scores_gemma":[0.9923887,0.0001137057,0.0007680429,0.0002926379,0.0001915961,0.0001753705,0.00008346916,0.00004881573,0.005937636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00322891,"threshold_uncertainty_score":0.7007911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00278419746473127,"score_gpt":0.1886515935818656,"score_spread":0.1858673961171343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}