{"id":"W1965123366","doi":"10.1016/s0169-328x(00)00079-6","title":"Identification of syntaxin 1A as a novel binding protein for presenilin-1","year":2000,"lang":"en","type":"article","venue":"Molecular Brain Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Presenilin; Biology; Transmembrane protein; Two-hybrid screening; Membrane protein; Cell biology; Syntaxin 3; Biochemistry; Syntaxin; Gene; Alzheimer's disease; Receptor; Membrane; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001485141,0.0001392612,0.000242509,0.0003862854,0.0001723189,0.00005188031,0.0002260991,0.0001067623,0.0004736028],"category_scores_gemma":[0.001208272,0.0001265278,0.0001769244,0.0006214263,0.0002365358,0.00007934753,0.00006546376,0.0002627417,0.0003110961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110127,"about_ca_system_score_gemma":0.0005284646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001187397,"about_ca_topic_score_gemma":0.000003223014,"domain_scores_codex":[0.996998,0.0002064218,0.0003457602,0.0004623472,0.001339134,0.000648348],"domain_scores_gemma":[0.9982204,0.00025104,0.0000490461,0.0006105707,0.0005060364,0.0003629012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001599653,0.00104777,0.0001875286,0.000325139,0.001433175,0.0001578084,0.00007607094,0.000005118607,0.9861224,0.001192723,0.0006728447,0.007179787],"study_design_scores_gemma":[0.003423632,0.001202197,0.000679176,0.0002230673,0.00008630721,0.00002835541,0.0001105121,0.000895599,0.9907686,0.001273775,0.001170378,0.0001384059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893833,0.0008410983,0.0004505869,0.002889683,0.000009004415,0.003887144,0.00009822079,0.00003300056,0.002407914],"genre_scores_gemma":[0.9912622,0.00001980611,0.0007252254,0.00003646186,0.00003962704,0.0009713738,0.000131991,0.00004828339,0.006765048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007041381,"threshold_uncertainty_score":0.5185619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06054178745839326,"score_gpt":0.4158389133071547,"score_spread":0.3552971258487614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}