{"id":"W1965132997","doi":"10.1373/clinchem.2009.133389","title":"Next-Generation Sequencing: A New Revolution in Molecular Diagnostics?","year":2009,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Mount Sinai Hospital","funders":"","keywords":"Computational biology; DNA sequencing; Biology; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002890617,0.0001513351,0.0001834577,0.00001380478,0.0000283992,0.00003470014,0.0001741819,0.0003153982,0.00002499867],"category_scores_gemma":[0.001991191,0.0001717494,0.0001278692,0.00009086679,0.00004747599,0.000004231777,0.00005229832,0.0001929443,0.00001036616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006881737,"about_ca_system_score_gemma":0.0003533982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002019475,"about_ca_topic_score_gemma":0.00002078258,"domain_scores_codex":[0.9987167,0.00003463373,0.0004680323,0.0004435518,0.0001012215,0.0002359028],"domain_scores_gemma":[0.9991932,0.00005574836,0.0001029161,0.0004040764,0.00005617703,0.0001879079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004646499,0.0001186139,0.005377648,0.00001027873,0.00001228919,0.00002899536,0.00000832789,0.0002986434,0.9564753,0.0001113925,0.02805056,0.009461553],"study_design_scores_gemma":[0.001897629,0.0003972506,0.003605914,0.00006044243,0.00004277951,0.00002437463,0.00002728822,0.001652663,0.9402913,0.002030145,0.04938677,0.0005834531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897265,0.003497449,0.00402549,0.0008377009,0.0001920839,0.0001285628,0.0000106971,0.00001470538,0.001566832],"genre_scores_gemma":[0.9919158,0.002751222,0.001530377,0.00165857,0.001476584,0.000006627982,0.0002958486,0.00001543345,0.0003494968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02133621,"threshold_uncertainty_score":0.7003736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06352844150315753,"score_gpt":0.3246632833817882,"score_spread":0.2611348418786307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}