{"id":"W1965134106","doi":"10.1002/cbic.200600547","title":"Converting Cytochrome c into a Peroxidase‐Like Metalloenzyme by Molecular Design","year":2007,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Photosynthetic Processes and Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cytochrome c peroxidase; Peroxidase; Heme; Hemeprotein; Chemistry; Horseradish peroxidase; Cytochrome c; Histidine; Enzyme kinetics; Cytochrome; Cytochrome P450 reductase; Stereochemistry; Protein design; Enzyme; Coenzyme Q – cytochrome c reductase; Biochemistry; Protein structure; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005969489,0.0003530525,0.0002823026,0.0001461616,0.0001289557,0.0006279016,0.0003183863,0.0003984799,0.0006227894],"category_scores_gemma":[0.0004022102,0.0001936307,0.0003437318,0.0001643684,0.0003489263,0.0003778028,0.0002374575,0.0006665765,0.0003214706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003515525,"about_ca_system_score_gemma":0.0003226339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001724567,"about_ca_topic_score_gemma":0.0002014218,"domain_scores_codex":[0.9997293,0.00007035865,0.00002408681,0.00007056319,0.00006697292,0.00003872434],"domain_scores_gemma":[0.9999,0.00001945821,0.00002459448,0.00001777814,0.00002201656,0.0000161498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001698733,0.0001984796,0.0004323806,0.0002593157,0.00005564756,0.0001562285,0.00005696508,0.001595353,0.9649642,0.007496139,0.0005605788,0.02405489],"study_design_scores_gemma":[0.0002648449,0.001795311,0.001052347,0.00003910936,0.0001165356,0.001006223,0.00004299163,0.00768362,0.930284,0.002416829,0.05526253,0.00003564604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7315068,0.006530317,0.2466616,0.003923008,0.0008681477,0.0005609138,0.0002509497,0.0006188116,0.009079397],"genre_scores_gemma":[0.8379507,0.004807597,0.1486474,0.0006732784,0.0000863926,0.0002757428,0.0004361008,0.0001008227,0.007021968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006279016,"threshold_uncertainty_score":0.00315702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006412365541678424,"score_gpt":0.2360651449853647,"score_spread":0.2296527794436862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}