{"id":"W1965160523","doi":"10.1021/bi901065t","title":"Elucidating the Formation of 6-Deoxyheptose: Biochemical Characterization of the GDP-d-glycero-d-manno-heptose C6 Dehydratase, DmhA, and Its Associated C4 Reductase, DmhB","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"State of Connecticut Department of Mental Health and Addiction Services","keywords":"Dehydratase; Heptose; Enzyme kinetics; Biosynthesis; Biochemistry; Reductase; Chemistry; Substrate (aquarium); Enzyme; Stereochemistry; Escherichia coli; NAD+ kinase; Biology; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000906427,0.0002963784,0.000189182,0.00008662553,0.00008405573,0.0001665381,0.0001398449,0.0002233574,0.0004965762],"category_scores_gemma":[0.0001494034,0.00009014017,0.0002277011,0.000127808,0.0001112834,0.0002318827,0.0001761308,0.0003262046,0.0002993517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707694,"about_ca_system_score_gemma":0.0001842794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006872365,"about_ca_topic_score_gemma":0.0005835769,"domain_scores_codex":[0.9999514,0.000007398051,0.000003801463,0.00001304162,0.0000135818,0.00001082896],"domain_scores_gemma":[0.9999154,0.00001338126,0.00001935225,0.000008231571,0.00002178435,0.00002195127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005839114,0.00000986841,0.0003327774,0.00004188061,0.000005401356,0.00006940484,0.00001929843,0.0001287114,0.9979374,0.0001027591,0.00001987942,0.001274252],"study_design_scores_gemma":[0.000002440705,0.0000662828,0.002551172,0.000003462358,0.00000633415,0.0001766074,0.00002577138,0.0007082164,0.9947098,0.00004605678,0.001698992,0.00000479923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876093,0.001538155,0.008317752,0.0001255817,0.00002369471,0.00002988307,0.0008742821,0.00004408487,0.001437285],"genre_scores_gemma":[0.9834456,0.001135101,0.009432728,0.00005059486,0.000009152764,0.00002162965,0.002731318,0.00003406961,0.003139787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006872365,"threshold_uncertainty_score":0.001661181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006537515568543776,"score_gpt":0.2196146474093138,"score_spread":0.21307713184077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}