{"id":"W1965160523","doi":"10.1021/bi901065t","title":"Elucidating the Formation of 6-Deoxyheptose: Biochemical Characterization of the GDP-<scp>d</scp>-<i>glycero</i>-<scp>d</scp>-<i>manno</i>-heptose C6 Dehydratase, DmhA, and Its Associated C4 Reductase, DmhB","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"State of Connecticut Department of Mental Health and Addiction Services","keywords":"Dehydratase; Heptose; Enzyme kinetics; Biosynthesis; Biochemistry; Reductase; Chemistry; Substrate (aquarium); Enzyme; Stereochemistry; Escherichia coli; NAD+ kinase; Biology; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000470099,0.000437471,0.0004165987,0.00004688778,0.000240778,0.0000722644,0.0007394237,0.0005752171,0.00000680419],"category_scores_gemma":[0.002637264,0.0003388076,0.0002085835,0.0004411112,0.0003420411,0.00004186332,0.0002842597,0.0002997612,0.000003440587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005602637,"about_ca_system_score_gemma":0.0001733412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004629759,"about_ca_topic_score_gemma":0.000002095929,"domain_scores_codex":[0.9973817,0.000151967,0.0008844111,0.0006065112,0.0004569873,0.0005183849],"domain_scores_gemma":[0.9973149,0.0001406378,0.001133602,0.0008960793,0.0003810474,0.000133755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000229155,0.0001646109,0.001096594,0.0001899183,0.00006177744,0.000001162688,0.0001679103,0.000002920028,0.9921221,0.00002812362,0.005956776,0.0001851906],"study_design_scores_gemma":[0.000614383,0.000116535,0.009524543,0.0002137074,0.00009813938,0.00002910435,0.0003740593,0.0001306825,0.9871941,0.00004491469,0.0015381,0.0001216957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967091,0.0009647685,0.0001681291,0.0001635612,0.000160355,0.0004608031,0.0006728474,0.00003105859,0.0006693423],"genre_scores_gemma":[0.9956746,0.0004258516,0.0001630179,0.0002364006,0.0002709265,0.00001341536,0.002107627,0.00004211882,0.001066081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00842795,"threshold_uncertainty_score":0.9999064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006537515568543776,"score_gpt":0.2196146474093138,"score_spread":0.21307713184077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}