{"id":"W1965278529","doi":"10.1021/jm200488a","title":"Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Université Laval; Hôpital Saint-François d'Assise","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Tubulin; Combretastatin; Stereochemistry; Biological activity; Structure–activity relationship; Combinatorial chemistry; In vitro; Microtubule; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001534811,0.0003398423,0.0002922147,0.0002222659,0.0001046596,0.0002193851,0.0002208429,0.0001749437,0.0008260399],"category_scores_gemma":[0.0001570568,0.000154927,0.0001866579,0.0002133163,0.0001750542,0.0001433719,0.0001023201,0.0002012704,0.0002872772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966226,"about_ca_system_score_gemma":0.0003909935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008041511,"about_ca_topic_score_gemma":0.002283328,"domain_scores_codex":[0.9999174,0.0000202205,0.000009654385,0.00001328822,0.00002076201,0.00001873185],"domain_scores_gemma":[0.9999096,0.000007677806,0.0000317347,0.000006686529,0.00001849551,0.00002584584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006226406,0.0001701796,0.0003870151,0.0001050024,0.00002180892,0.00009235134,0.00002874536,0.001450659,0.98784,0.0002092897,0.00007823926,0.008994067],"study_design_scores_gemma":[0.0004408169,0.007792566,0.003599046,0.00001073847,0.00008805533,0.0003072516,0.0000333782,0.001557076,0.9795322,0.00004288597,0.006578993,0.00001710868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935069,0.002253934,0.001928263,0.00005376645,0.00001700817,0.0001502136,0.0003192489,0.00004147615,0.001729107],"genre_scores_gemma":[0.9901955,0.002967582,0.004272619,0.00003716066,0.000009721712,0.00008330705,0.0006988145,0.000009634676,0.001725696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008260399,"threshold_uncertainty_score":0.002763331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1229097849984163,"score_gpt":0.2803816524649303,"score_spread":0.157471867466514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}