{"id":"W1965301111","doi":"10.1517/14728222.2011.537656","title":"The promise and challenges of targeting RSK for the treatment of cancer","year":2010,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Targets","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Kinase; Serine; Threonine; Protein-Serine-Threonine Kinases; Biology; Phosphorylation; Cancer; Cancer research; Ribosomal s6 kinase; Cell biology; Genetics; Protein kinase A; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001209005,0.0001042204,0.000107571,0.000009385394,0.0001191551,0.000005388687,0.000110335,0.00007034424,0.000007241466],"category_scores_gemma":[0.00001776601,0.00005193818,0.0000683768,0.00001294847,0.00009896483,0.000001314505,0.00001378252,0.00002958615,2.244284e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003514331,"about_ca_system_score_gemma":0.00003045697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002142652,"about_ca_topic_score_gemma":0.00003614936,"domain_scores_codex":[0.9994806,0.00002724347,0.0001381835,0.0001587363,0.00006550321,0.0001297149],"domain_scores_gemma":[0.9994947,0.00009472292,0.00009387356,0.000240892,0.00004941738,0.00002635334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002566881,0.000119816,0.0001230012,0.00001369223,0.0001284477,4.86422e-8,0.001055006,0.000002094983,0.6997027,0.002611975,0.0002561621,0.2957303],"study_design_scores_gemma":[0.0004290827,0.0007072011,0.0005309065,0.000004634447,0.000003211119,4.847493e-7,0.0002307666,0.00004848463,0.4211972,0.0001024663,0.5766961,0.00004947952],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1297221,0.8621108,0.0001856416,0.004925274,0.001749554,0.001022645,0.00004161179,0.0000092381,0.0002330777],"genre_scores_gemma":[0.8026144,0.1963223,0.0001873563,0.00008647243,0.000405498,0.0002798344,0.00001094494,0.00001511452,0.0000780709],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.6728923,"threshold_uncertainty_score":0.2117977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03705129146068916,"score_gpt":0.315687583912151,"score_spread":0.2786362924514619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}