{"id":"W1965357535","doi":"10.1021/jm0302748","title":"Synthesis and Use of Novel Ether Phospholipid Enantiomers To Probe the Molecular Basis of the Antitumor Effects of Alkyllysophospholipids:  Correlation of Differential Activation of c-Jun NH<sub>2</sub>-Terminal Protein Kinase with Antiproliferative Effects in Neuronal Tumor Cells","year":2004,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chemistry; Enantioselective synthesis; Ether; Enantiomer; Phospholipid; Stereochemistry; Cell growth; Differential effects; Potency; Biochemistry; In vitro; Organic chemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497454,0.0003531392,0.0002061833,0.0002021898,0.0001177106,0.0001961284,0.0001804843,0.0002113053,0.0006439802],"category_scores_gemma":[0.0001531265,0.0001298234,0.0001892995,0.0002064138,0.0001474006,0.000257413,0.0001980935,0.0004317613,0.000212077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002140402,"about_ca_system_score_gemma":0.0002886904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003672479,"about_ca_topic_score_gemma":0.000736251,"domain_scores_codex":[0.9999404,0.00001173493,0.000007025611,0.00001049234,0.00001525628,0.00001505516],"domain_scores_gemma":[0.9998987,0.00001433114,0.00003225338,0.00001300697,0.00002024841,0.0000213918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224002,0.00002270385,0.0001475467,0.00002248088,0.000005441333,0.00005730629,0.00001051039,0.0001331182,0.9971775,0.0001536326,0.00001202029,0.002135211],"study_design_scores_gemma":[0.00001136766,0.0001566816,0.0003365525,0.000001444338,0.00001299999,0.00007815682,0.000009329055,0.0001264158,0.9984217,0.00002960337,0.0008132703,0.000002439178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884,0.001347077,0.00720131,0.00009978053,0.00001878043,0.0001090461,0.0005607051,0.00003219611,0.002231205],"genre_scores_gemma":[0.9865806,0.002106949,0.009079361,0.00006004177,0.000008758095,0.00006849907,0.0005945786,0.00002027547,0.001480886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006439802,"threshold_uncertainty_score":0.002154291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004875162006600132,"score_gpt":0.2088952600817025,"score_spread":0.2040200980751024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}