{"id":"W1965359069","doi":"10.1210/en.2011-1438","title":"Ubiquitin-Proteasomal Degradation of COX-2 in TGF-β Stimulated Human Endometrial Cells Is Mediated Through Endoplasmic Reticulum Mannosidase I","year":2011,"lang":"en","type":"article","venue":"Endocrinology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Canadian Institutes of Health Research","keywords":"Small interfering RNA; MG132; Endoplasmic reticulum; Stromal cell; Gene knockdown; SMAD; Proteasome inhibitor; Cell biology; Proteasome; Protein degradation; Endoplasmic-reticulum-associated protein degradation; Chemistry; Transforming growth factor; Internal medicine; Biology; Endocrinology; Cell culture; Unfolded protein response; Cancer research; Transfection; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407197,0.0003181942,0.0002159414,0.0001477866,0.0001786566,0.0001912129,0.00009402595,0.0001168593,0.001303262],"category_scores_gemma":[0.00008715732,0.0001601477,0.0003535933,0.0001328318,0.0001069939,0.0001252811,0.000144713,0.0002869058,0.0003190569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001700084,"about_ca_system_score_gemma":0.0001739407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082633,"about_ca_topic_score_gemma":0.0009046239,"domain_scores_codex":[0.9998989,0.0000140838,0.00001339831,0.0000229851,0.00002671634,0.00002392819],"domain_scores_gemma":[0.9999467,0.0000060705,0.00001979695,0.000007777226,0.000008864271,0.00001084629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001892229,0.000019979,0.0003282016,0.00008176661,0.00001073967,0.00008020207,0.00001403916,0.00002170071,0.9981293,0.00004445005,0.00003312212,0.001047249],"study_design_scores_gemma":[0.00002355267,0.0001981437,0.01372658,0.00000922606,0.00002180345,0.0004592875,0.00003380296,0.0005742884,0.9820732,0.00003022107,0.002845613,0.00000437264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881228,0.006154565,0.003474893,0.0001200626,0.00005159271,0.00003329957,0.0005255364,0.000053057,0.001464287],"genre_scores_gemma":[0.9876717,0.003453566,0.003737951,0.00007432555,0.00001916994,0.00005706863,0.001098763,0.0000112453,0.003876089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303262,"threshold_uncertainty_score":0.004359841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05246352085943738,"score_gpt":0.2951182969000385,"score_spread":0.2426547760406011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}