{"id":"W1965396461","doi":"10.1021/mp900145g","title":"Development of a Poly(<scp>d</scp>,<scp>l</scp>-lactic-<i>co</i>-glycolic acid) Nanoparticle Formulation of STAT3 Inhibitor JSI-124: Implication for Cancer Immunotherapy","year":2009,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"PLGA; Glycolic acid; Nanocarriers; Chemistry; Cancer immunotherapy; Adjuvant; STAT3; Immune system; Drug delivery; In vitro; Cancer research; Immunotherapy; Lactic acid; Biochemistry; Phosphorylation; Immunology; Medicine; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005461148,0.0003848976,0.0005469669,0.0002518336,0.0002430514,0.00002664392,0.0003677573,0.0003140314,0.00002389354],"category_scores_gemma":[0.0002160929,0.0003874576,0.0002186027,0.0003794598,0.0001440202,0.0002219809,0.00004426282,0.0002691423,0.00002113039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490938,"about_ca_system_score_gemma":0.0003908342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000192369,"about_ca_topic_score_gemma":0.000002721333,"domain_scores_codex":[0.9975201,0.0002391018,0.00100686,0.000383235,0.0001504774,0.000700168],"domain_scores_gemma":[0.9980562,0.000414492,0.0006768728,0.0004796735,0.0003234146,0.00004928712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005381098,0.0005213707,0.0001228723,0.00007218081,0.000523406,0.000001080492,0.004572945,0.00002552649,0.9379795,0.0003901638,0.0004621713,0.05479069],"study_design_scores_gemma":[0.003965587,0.0003980505,0.00149874,0.00005043967,0.00009641458,0.00001317846,0.000375624,0.0000575488,0.7758737,0.0001159191,0.2174539,0.0001009047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511049,0.03929577,0.007696501,0.0001254859,0.0003333377,0.001130194,0.00008160374,0.0001105606,0.0001216767],"genre_scores_gemma":[0.9949793,0.001009065,0.002482067,0.0005773503,0.00002917495,0.000181921,0.000132987,0.00008022293,0.0005278871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2169917,"threshold_uncertainty_score":0.9998577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02537323430555254,"score_gpt":0.3303159722440803,"score_spread":0.3049427379385277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}