{"id":"W1965396461","doi":"10.1021/mp900145g","title":"Development of a Poly(<scp>d</scp>,<scp>l</scp>-lactic-<i>co</i>-glycolic acid) Nanoparticle Formulation of STAT3 Inhibitor JSI-124: Implication for Cancer Immunotherapy","year":2009,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"PLGA; Glycolic acid; Nanocarriers; Chemistry; Cancer immunotherapy; Adjuvant; STAT3; Immune system; Drug delivery; In vitro; Cancer research; Immunotherapy; Lactic acid; Biochemistry; Phosphorylation; Immunology; Medicine; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008995478,0.0002692419,0.0001369467,0.0001445284,0.00008730372,0.0002361856,0.0001798897,0.0002819674,0.0004349055],"category_scores_gemma":[0.00009433721,0.0001260595,0.00022756,0.0001033771,0.0001551017,0.0002114688,0.0001258771,0.0003400774,0.0002592393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003123852,"about_ca_system_score_gemma":0.0002515966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006686692,"about_ca_topic_score_gemma":0.0007742749,"domain_scores_codex":[0.9999459,0.000006057933,0.000005740297,0.00001371709,0.00002099078,0.000007598046],"domain_scores_gemma":[0.9999409,0.000007974743,0.00002422579,0.000004057046,0.00001118286,0.00001172174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002041557,0.00001751031,0.00004081848,0.00002746663,0.000003240219,0.00001600165,0.000004588537,0.0002119733,0.9975816,0.00005719233,0.00002166249,0.001997485],"study_design_scores_gemma":[0.00001239943,0.0002223233,0.0004285081,0.000003061333,0.00001295657,0.00009542119,0.000003209963,0.001768841,0.9959979,0.00001414231,0.00143771,0.000003586421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491575,0.003120283,0.04352441,0.0002599961,0.00006776494,0.0001954131,0.000252501,0.0002330008,0.003189142],"genre_scores_gemma":[0.9652259,0.001769304,0.02944257,0.000100669,0.00002212406,0.00009511144,0.0003017572,0.00004520558,0.002997405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006686692,"threshold_uncertainty_score":0.002266526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02537323430555254,"score_gpt":0.3303159722440803,"score_spread":0.3049427379385277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}