{"id":"W1965401351","doi":"10.1038/mt.sj.6300119","title":"Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene Therapy","year":2007,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Office of Research Infrastructure Programs, National Institutes of Health","keywords":"Biodistribution; Genetic enhancement; Luciferase; Bioluminescence imaging; Cancer research; Molecular biology; Biology; Virology; In vivo; Gene; Transfection; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004803319,0.0001510121,0.0001180955,0.00004928198,0.00009150802,0.00002254649,0.0001822708,0.00008523469,0.000008773438],"category_scores_gemma":[0.00001682113,0.0001161922,0.00009318438,0.0001226477,0.0001542222,0.000003820705,0.00002984196,0.00006300245,4.567148e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001920379,"about_ca_system_score_gemma":0.00004166122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001531072,"about_ca_topic_score_gemma":0.00001690653,"domain_scores_codex":[0.9989983,0.00006662517,0.0002052122,0.0002664794,0.000182649,0.0002807518],"domain_scores_gemma":[0.999329,0.00001927429,0.0000934834,0.0003305372,0.0001788128,0.00004884777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001743537,0.00004696854,0.001196517,0.000003827728,0.00006503362,7.995566e-7,0.00004628135,0.0001421332,0.8302526,0.00002956353,0.00002257006,0.1664502],"study_design_scores_gemma":[0.001458277,0.001096537,0.006588419,0.000003848667,0.000005540106,0.000003870446,0.00002612252,0.0003462298,0.9812424,0.0002212036,0.008871922,0.000135629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466754,0.01683931,0.03536359,0.0004094381,0.00006164317,0.0005664564,0.00005296519,0.000008489671,0.00002267416],"genre_scores_gemma":[0.9958495,0.002804058,0.0004247824,0.000521673,0.00013416,0.00005468987,0.0001401009,0.00003260714,0.00003838391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1663146,"threshold_uncertainty_score":0.4738181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967722029380644,"score_gpt":0.3191932894365889,"score_spread":0.2995160691427825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}