{"id":"W1965410481","doi":"10.1016/j.febslet.2005.12.036","title":"Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)","year":2005,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"ABCC1; Chemistry; Glutathione; Xenobiotic; Transporter; Major facilitator superfamily; ATP-binding cassette transporter; Biochemistry; Multidrug Resistance-Associated Proteins; Transport protein; Organic anion transporter 1; Organic cation transport proteins; Multiple drug resistance; Membrane transport protein; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000260959,0.0006332437,0.001641601,0.0001776173,0.0001036192,0.00002551033,0.0001443722,0.0003863467,0.0001361337],"category_scores_gemma":[0.000007095266,0.0005167394,0.0004511231,0.0002457848,0.0001379258,0.0001194444,0.000006048284,0.000691122,0.0001105379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001206568,"about_ca_system_score_gemma":0.000116876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001557904,"about_ca_topic_score_gemma":0.0000977229,"domain_scores_codex":[0.997499,0.00006536903,0.0007740853,0.0007640637,0.0004006071,0.0004968423],"domain_scores_gemma":[0.9989852,0.00002752928,0.0003042762,0.0003964198,0.00004156834,0.0002449708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002516112,0.0002247809,0.00001375522,0.05235696,0.0004513147,0.0008887225,0.0002234631,9.367228e-8,0.001951599,0.00002056982,0.008393206,0.9352239],"study_design_scores_gemma":[0.0008067382,0.00003034537,0.00002991908,0.02254191,0.001238153,0.00004128145,0.00001351709,2.399102e-7,0.000182934,0.00001164033,0.9745428,0.0005605296],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002323283,0.9924114,0.0002017987,0.001255956,0.000157355,0.002329972,0.0005015439,0.0001605032,0.0006582331],"genre_scores_gemma":[0.0001033877,0.9873496,0.002008863,0.0007603727,0.0003596051,0.0003347982,0.002622562,0.0001395667,0.006321197],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9661496,"threshold_uncertainty_score":0.9997284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732061473803282,"score_gpt":0.2729705009886044,"score_spread":0.2356498862505716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}