{"id":"W1965445778","doi":"10.1371/journal.pone.0018919","title":"Structural and Histone Binding Ability Characterizations of Human PWWP Domains","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; Division of Materials Research; Office of Science; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; National Center for Research Resources; Ontario Genomics Institute; Wellcome Trust; National Institutes of Health; Ontario Genomics; Genome Canada; Ontario Innovation Trust; GlaxoSmithKline; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy; University of Chicago; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chromodomain; Histone; Chemistry; DNA-binding domain; Biology; DNA; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059443,0.000244384,0.0001227103,0.0002114186,0.0001178601,0.0001306018,0.0001835998,0.0001554818,0.0009871969],"category_scores_gemma":[0.000215119,0.00006573137,0.0002367477,0.0003249702,0.000120389,0.0001419848,0.0001105771,0.0002386175,0.0002561236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184271,"about_ca_system_score_gemma":0.00008515887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008027217,"about_ca_topic_score_gemma":0.0004292535,"domain_scores_codex":[0.9999504,0.000005233222,0.000004258115,0.00001391856,0.00001728015,0.000008887504],"domain_scores_gemma":[0.9998772,0.00003183321,0.00002838967,0.00001299025,0.00002670949,0.00002288304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002881767,0.00005526937,0.005085748,0.0001129439,0.00002396916,0.0002270951,0.00009949256,0.000924986,0.987575,0.0002463317,0.0001702202,0.005190719],"study_design_scores_gemma":[0.000037791,0.0003352658,0.06546677,0.00001578371,0.00006555556,0.00227701,0.0001374656,0.007534666,0.9143719,0.0003358681,0.009403839,0.00001805396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960259,0.0009244193,0.001937712,0.00002666946,0.000003681623,0.000008683576,0.0005820401,0.00001454936,0.0004762486],"genre_scores_gemma":[0.9940354,0.0003596295,0.002441179,0.00002198697,0.000005296222,0.00001464188,0.002529319,0.000007581815,0.0005849433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009871969,"threshold_uncertainty_score":0.003302515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05893307122488449,"score_gpt":0.2608191659931047,"score_spread":0.2018860947682202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}