{"id":"W1965445778","doi":"10.1371/journal.pone.0018919","title":"Structural and Histone Binding Ability Characterizations of Human PWWP Domains","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Biological and Environmental Research; Division of Materials Research; Office of Science; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; National Center for Research Resources; Ontario Genomics Institute; Wellcome Trust; National Institutes of Health; Ontario Genomics; Genome Canada; Ontario Innovation Trust; GlaxoSmithKline; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy; University of Chicago; Canadian Institutes of Health Research; National Science Foundation","keywords":"Chromodomain; Histone; Chemistry; DNA-binding domain; Biology; DNA; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005800203,0.00007158516,0.0001036352,0.00002075432,0.00006173594,0.00000392328,0.00008615767,0.00005603485,0.00007412106],"category_scores_gemma":[0.00007064727,0.00007392312,0.00002688898,0.0000364347,0.0001264592,0.000002826939,0.00006512799,0.00003564542,0.000001499837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008037363,"about_ca_system_score_gemma":0.00001755624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009584549,"about_ca_topic_score_gemma":0.000003489322,"domain_scores_codex":[0.9994889,0.00002617709,0.0001357305,0.0001744079,0.00007851618,0.00009627265],"domain_scores_gemma":[0.9995761,0.000004415729,0.00007036224,0.0002385176,0.00005309582,0.00005752387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001690679,0.0001805623,0.06282401,0.00004677573,0.00005624176,6.078303e-7,0.0001613948,6.915661e-8,0.9365559,0.0001251422,0.000004156736,0.00002827866],"study_design_scores_gemma":[0.0002031176,0.00009803462,0.08367144,0.00002024763,0.00005111527,6.82482e-7,0.00001806548,0.000006075586,0.9156885,0.000156483,0.000003631176,0.00008262775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993834,0.00007327075,0.00002119972,0.000008127963,0.00001864052,0.0001082137,0.00006807314,0.00001096251,0.000308065],"genre_scores_gemma":[0.998705,0.000006436986,0.001004739,0.00002043455,0.00004814683,0.000009044359,0.0001162609,0.00001112866,0.00007881866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02086737,"threshold_uncertainty_score":0.3014497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05893307122488449,"score_gpt":0.2608191659931047,"score_spread":0.2018860947682202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}