{"id":"W1965447971","doi":"10.1074/jbc.m112.397976","title":"S-Nitrosylation Inhibits Pannexin 1 Channel Function","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; American Heart Association; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; University of Connecticut","keywords":"S-Nitrosylation; Nitrosylation; Cysteine; Nitric oxide; Pannexin; HEK 293 cells; Soluble guanylyl cyclase; Chemistry; S-Nitrosoglutathione; Cell biology; Dithiothreitol; Biochemistry; Mutant; Biophysics; Biology; Glutathione; Intracellular; Guanylate cyclase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004122924,0.0001393207,0.0001872906,0.0000213138,0.00005006423,0.000009388491,0.0001286975,0.0003472227,0.0001460238],"category_scores_gemma":[0.0002246655,0.00009817988,0.0001671709,0.00006497921,0.00007549302,0.000008052048,0.00006832984,0.0001918047,0.000009483326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001685571,"about_ca_system_score_gemma":0.00002980988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.285778e-7,"about_ca_topic_score_gemma":2.190221e-7,"domain_scores_codex":[0.9991101,0.00005398946,0.000339436,0.0001372353,0.00008873613,0.0002704896],"domain_scores_gemma":[0.9992818,0.00002064001,0.0002758244,0.0001319746,0.0001394166,0.000150333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002873944,0.0001111482,0.007629628,0.000008186892,0.00004101346,0.000001283157,0.00001248577,0.000006431999,0.989081,0.00001536523,0.0009665562,0.001839521],"study_design_scores_gemma":[0.0006121269,0.0006551257,0.02278698,0.00001342603,0.00002564734,0.0002815056,0.0001282125,0.000007049456,0.9107696,0.0001760606,0.06433684,0.000207379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947185,0.002432241,0.001193935,0.000132324,0.0002811264,0.00003947867,0.000006632753,0.000006926125,0.001188833],"genre_scores_gemma":[0.996896,0.0002251818,0.0001377922,0.0002519047,0.002164355,0.000002564211,0.00005446104,0.000008477656,0.000259307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07831135,"threshold_uncertainty_score":0.4003659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481980182287588,"score_gpt":0.2472788852072507,"score_spread":0.2224590833843748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}