{"id":"W1965454317","doi":"10.1371/journal.ppat.1004419","title":"Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Learning Partnership; Child and Family Research Institute; Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Institute for Advanced Research","keywords":"Biology; DNA methylation; Epigenetics; Leishmania donovani; Innate immune system; Intracellular parasite; Leishmania; Cell biology; Genetics; Visceral leishmaniasis; Gene; Gene expression; Immune system; Leishmaniasis; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005303349,0.0002542711,0.0004799731,0.000391984,0.0001508714,0.00004225484,0.00009137735,0.000117649,0.0001535212],"category_scores_gemma":[0.00150026,0.0002243526,0.00008192401,0.0005047814,0.0001136705,0.00009077541,0.0001161498,0.0002661152,0.0001822162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001937086,"about_ca_system_score_gemma":0.00004224256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002113111,"about_ca_topic_score_gemma":0.00372679,"domain_scores_codex":[0.9979529,0.0002501834,0.0003239698,0.0004731441,0.0004960548,0.0005037782],"domain_scores_gemma":[0.9988422,0.0002578677,0.0001143899,0.0004194416,0.0002155218,0.000150534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000658737,0.0003026731,0.5034726,0.0002579466,0.00009454173,0.00006903338,0.0004595603,0.000005242269,0.4855461,0.00007576519,0.0001354971,0.009515161],"study_design_scores_gemma":[0.0007880568,0.0005259045,0.883261,0.0001367301,0.0001023213,0.0000150993,0.00005850569,0.0003110141,0.1126954,0.0001228441,0.001784344,0.0001988362],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948962,0.0004978324,0.0002845004,0.001491148,0.0001398783,0.000703371,0.00002415692,0.0001409295,0.00182198],"genre_scores_gemma":[0.997565,0.000891095,0.000377651,0.0001451264,0.000405745,0.0001584098,0.0000379764,0.00005461553,0.0003643953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3797883,"threshold_uncertainty_score":0.9148833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03621301801311464,"score_gpt":0.2956764719991787,"score_spread":0.2594634539860641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}