{"id":"W1965454317","doi":"10.1371/journal.ppat.1004419","title":"Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Learning Partnership; Child and Family Research Institute; Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Institute for Advanced Research","keywords":"Biology; DNA methylation; Epigenetics; Leishmania donovani; Innate immune system; Intracellular parasite; Leishmania; Cell biology; Genetics; Visceral leishmaniasis; Gene; Gene expression; Immune system; Leishmaniasis; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539386,0.0001356402,0.0001585275,0.0002176868,0.0001189911,0.0001606705,0.00008885271,0.0001729117,0.0007404221],"category_scores_gemma":[0.0001851843,0.0001202931,0.0001316421,0.0001071439,0.0001830717,0.0000811127,0.0002424223,0.0002168629,0.0001176342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001088607,"about_ca_system_score_gemma":0.0001015665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003437751,"about_ca_topic_score_gemma":0.0007028258,"domain_scores_codex":[0.9998858,0.00002712666,0.000006576489,0.00003162247,0.0000191314,0.00002975144],"domain_scores_gemma":[0.9999284,0.00001360737,0.00002197879,0.000009294246,0.00001187457,0.00001482778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000248064,0.0000153409,0.00674859,0.0000365192,0.00001425975,0.00006577293,0.00005503244,0.00003374692,0.9908071,0.00005663372,0.00002393569,0.001894997],"study_design_scores_gemma":[0.0000489764,0.001094878,0.3892163,0.00002593003,0.0001003522,0.001606853,0.0004347264,0.001189013,0.6020026,0.0004388259,0.003820615,0.00002094708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973367,0.001012708,0.0007684123,0.00004990439,0.000007425183,0.000009201455,0.0001428188,0.0000165006,0.0006563947],"genre_scores_gemma":[0.9988664,0.0002543395,0.0002863161,0.00003513751,0.000002309889,0.00001070203,0.000136329,0.000002802242,0.0004058328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007404221,"threshold_uncertainty_score":0.002476931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03621301801311464,"score_gpt":0.2956764719991787,"score_spread":0.2594634539860641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}