{"id":"W1965458832","doi":"10.2165/00003088-200544050-00001","title":"Pharmacokinetics of Proton Pump Inhibitors in Children","year":2005,"lang":"en","type":"review","venue":"Clinical Pharmacokinetics","topic":"Gastroesophageal reflux and treatments","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Lansoprazole; Omeprazole; Pantoprazole; Esomeprazole; CYP2C19; Pharmacokinetics; Pharmacology; Rabeprazole; Proton-pump inhibitor; Medicine; Enteric coating; CYP3A4; Population; Oral administration; Gastroenterology; Chemistry; Internal medicine; Cytochrome P450; Dosage form; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000721806,0.0008748362,0.004001889,0.0004865278,0.0000278107,0.00001593242,0.000449391,0.0007148763,0.0004212514],"category_scores_gemma":[0.0002920657,0.0006853525,0.00149532,0.0007369322,0.0003383713,0.0000562484,0.0002555567,0.001935591,0.0002346727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001700605,"about_ca_system_score_gemma":0.0004609019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003762137,"about_ca_topic_score_gemma":2.357453e-7,"domain_scores_codex":[0.9937423,0.0003943907,0.003612618,0.0009184738,0.0006524223,0.0006797335],"domain_scores_gemma":[0.997044,0.0003880236,0.001118686,0.0007173815,0.0001581202,0.0005737607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005817324,0.002539485,0.03740158,0.006319354,0.0008589033,0.0002583086,0.000007856471,0.000003103562,0.000001246435,0.00000266054,0.0009489303,0.9516004],"study_design_scores_gemma":[0.007823872,0.0009844045,0.004631282,0.00735164,0.007752055,0.0001931898,8.85726e-7,0.00003353348,0.0001371283,0.000009635992,0.9706891,0.0003933081],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005672019,0.9861346,0.000003785429,0.00003650826,0.0006034713,0.006148313,0.0001743878,0.0000771646,0.001149704],"genre_scores_gemma":[0.008774308,0.9870327,0.0006083138,0.0002039376,0.001918453,0.0002647004,0.0004258897,0.000178399,0.0005932669],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9697402,"threshold_uncertainty_score":0.9995598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09888409871956902,"score_gpt":0.4787984253831883,"score_spread":0.3799143266636192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}