{"id":"W1965472986","doi":"10.1371/journal.pone.0108677","title":"Investigation of the Josephin Domain Protein-Protein Interaction by Molecular Dynamics","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Molecular dynamics; Fibrillogenesis; Polyglutamine tract; Biophysics; Spinocerebellar ataxia; Plasma protein binding; Chemistry; Protein folding; Protein structure; Protein–protein interaction; Cell biology; Fibril; Biology; Biochemistry; Mutant; Computational chemistry; Huntingtin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001942926,0.0005484633,0.0004668354,0.0002839925,0.0006631226,0.0004023932,0.0005316655,0.0006347147,0.0009207969],"category_scores_gemma":[0.0004669101,0.0002806339,0.0004087908,0.000271203,0.0004076141,0.0007646595,0.0003472006,0.0005995707,0.0001000324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000503009,"about_ca_system_score_gemma":0.0004584534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003067975,"about_ca_topic_score_gemma":0.001902441,"domain_scores_codex":[0.9999135,0.00001983972,0.000003416721,0.0000192938,0.00002243498,0.00002158627],"domain_scores_gemma":[0.9998573,0.00006334004,0.0000212219,0.00001146571,0.00002112518,0.00002550931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004011397,0.0004907814,0.009315332,0.0003289138,0.0003384397,0.0005834851,0.0003699213,0.8138077,0.1409912,0.01970361,0.0009873689,0.01268218],"study_design_scores_gemma":[0.00001936175,0.00005401488,0.001153533,0.000003690423,0.00001180304,0.00001589328,0.00001975515,0.9949432,0.002787655,0.0006258311,0.0003574548,0.000007863501],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772065,0.0005499473,0.01746537,0.0002875282,0.0000384645,0.00004177501,0.0001335884,0.0001314588,0.004145535],"genre_scores_gemma":[0.9928906,0.0003968086,0.006059903,0.00002805773,0.00001249076,0.00004951461,0.0001590276,0.00003163291,0.0003719155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003067975,"threshold_uncertainty_score":0.006100237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937396658625269,"score_gpt":0.2194160655956057,"score_spread":0.190042099009353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}