{"id":"W1965473863","doi":"10.1110/ps.083443908","title":"The proteosomal degradation of fusion proteins cannot be predicted from the proteosome susceptibility of their individual components","year":2008,"lang":"en","type":"article","venue":"Protein Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Petro-Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Degradation (telecommunications); Chemistry; Fusion; Proteasome; Fusion protein; Computational biology; Biophysics; Cell biology; Biology; Biochemistry; Computer science; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001424926,0.0001896174,0.0001803633,0.00003826209,0.0007728901,0.00003323207,0.001276653,0.0001094839,0.00001394786],"category_scores_gemma":[0.0006815246,0.0001066942,0.00008703765,0.0004568206,0.002255791,0.00002433864,0.0005093076,0.0001846606,9.682399e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002140914,"about_ca_system_score_gemma":0.0005799945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000797004,"about_ca_topic_score_gemma":0.0002644383,"domain_scores_codex":[0.9976116,0.0002698475,0.0004532391,0.0004870408,0.0008190016,0.0003592175],"domain_scores_gemma":[0.9981858,0.0000484271,0.0004130421,0.0008551849,0.0004098712,0.00008769744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001777449,0.0001060178,0.01719462,0.00001814191,0.00001540508,4.002402e-7,0.0005078829,0.000003049194,0.9797348,0.0000811996,0.00002318989,0.002137577],"study_design_scores_gemma":[0.0004441742,0.0004953856,0.08673902,0.00004899368,0.000005636532,0.000005136241,0.0001125766,0.0001036114,0.9110448,0.0002243917,0.0006583258,0.0001179643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942861,0.0002484403,0.000353631,0.0004162769,0.00005209231,0.004088378,0.0004080309,0.00001606137,0.0001310234],"genre_scores_gemma":[0.9977751,0.00002877974,0.001348351,0.00003997558,0.00007549611,0.0005275391,0.0001044102,0.00001230631,0.0000880743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0695444,"threshold_uncertainty_score":0.8311556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816484733025694,"score_gpt":0.2469601759208788,"score_spread":0.2087953285906219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}