{"id":"W1965473863","doi":"10.1110/ps.083443908","title":"The proteosomal degradation of fusion proteins cannot be predicted from the proteosome susceptibility of their individual components","year":2008,"lang":"en","type":"article","venue":"Protein Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Petro-Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Degradation (telecommunications); Chemistry; Fusion; Proteasome; Fusion protein; Computational biology; Biophysics; Cell biology; Biology; Biochemistry; Computer science; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005816017,0.000492566,0.0003466098,0.0004402855,0.0001716115,0.0004817062,0.0001588628,0.0004261089,0.0007392685],"category_scores_gemma":[0.0005590796,0.0002584654,0.0005472891,0.0001607592,0.0003419759,0.0005749094,0.0003243925,0.0005945839,0.0005326914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003437932,"about_ca_system_score_gemma":0.0002049721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000219359,"about_ca_topic_score_gemma":0.0001822312,"domain_scores_codex":[0.9996296,0.00006037014,0.00004085167,0.00009582029,0.0001157851,0.00005744732],"domain_scores_gemma":[0.9993328,0.0002248919,0.0001954674,0.00007923033,0.00009246336,0.00007511485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006172675,0.000009942885,0.0008552368,0.00003930924,0.00002018573,0.00004487766,0.0000199147,0.0001124514,0.9974262,0.0001780498,0.00001011014,0.001222026],"study_design_scores_gemma":[0.000005382952,0.0002074078,0.01254585,0.000008563821,0.00003158382,0.0008312335,0.00003549254,0.002768476,0.9818131,0.0003279677,0.001414547,0.00001035591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720342,0.001448047,0.02498462,0.00009610383,0.00002222687,0.00005712674,0.0002058092,0.000102396,0.001049509],"genre_scores_gemma":[0.9928392,0.0004067403,0.00549523,0.00004418091,0.000006709404,0.00003916351,0.0003678679,0.00002874301,0.0007721951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007392685,"threshold_uncertainty_score":0.003075898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816484733025694,"score_gpt":0.2469601759208788,"score_spread":0.2087953285906219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}