{"id":"W1965492289","doi":"10.1016/j.mcn.2003.11.014","title":"Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Excitotoxicity; Mitochondrial permeability transition pore; Biology; NMDA receptor; Huntingtin; Cell biology; Huntington's disease; Mitochondrion; Programmed cell death; Caspase; Glutamate receptor; Apoptosis; Receptor; Biochemistry; Internal medicine; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002146097,0.0005547662,0.0005039411,0.0007737288,0.0003344676,0.0002894659,0.0004471291,0.0006494722,0.00154214],"category_scores_gemma":[0.0001855727,0.0002861488,0.0002836042,0.0002964233,0.0005016646,0.0004423557,0.0002829401,0.001632322,0.0003303401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004182453,"about_ca_system_score_gemma":0.0002860421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009925436,"about_ca_topic_score_gemma":0.001322455,"domain_scores_codex":[0.9998074,0.00002615446,0.00002640443,0.00003995137,0.0000514427,0.00004858009],"domain_scores_gemma":[0.9997236,0.00003694771,0.00008719027,0.000042143,0.00003543548,0.00007462376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003614392,0.0001029471,0.0002511906,0.00004606013,0.00001513409,0.0005492228,0.00003777604,0.00006958613,0.9973908,0.0003026719,0.00007807493,0.0007951205],"study_design_scores_gemma":[0.0001056053,0.0009113806,0.008068451,0.00002171878,0.00008503464,0.002294891,0.00007854509,0.001435358,0.9854808,0.0003321572,0.001170844,0.00001518196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962015,0.000973277,0.001136271,0.0001573414,0.00005772123,0.00002119243,0.0003268715,0.00007666741,0.001049101],"genre_scores_gemma":[0.9948556,0.0007819541,0.0007346319,0.00004316658,0.00001866848,0.00006310426,0.0002829926,0.00002159662,0.003198173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154214,"threshold_uncertainty_score":0.00515902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426268341663908,"score_gpt":0.2059625640708694,"score_spread":0.1916998806542304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}