{"id":"W1965497380","doi":"10.1038/nature10358","title":"Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":550,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; University of Ottawa; Wilfrid Laurier University; Ottawa Hospital; Western University; Jennerex Biotherapeutics (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Oncolytic virus; Transgene; Cancer; Cancer research; Small interfering RNA; Biology; Cancer cell; Virotherapy; Virus; Systemic administration; Virology; Cell culture; Gene; Transfection; In vivo; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819299,0.0001404209,0.0001745642,0.000102596,0.00003314793,0.000004597042,0.000306786,0.0008121516,0.0001616189],"category_scores_gemma":[0.00005531284,0.0001361012,0.00006779509,0.0001721734,0.00006357845,0.000002445725,0.00007164068,0.0007448571,0.000008407961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004668557,"about_ca_system_score_gemma":0.0002326134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003674429,"about_ca_topic_score_gemma":0.005015461,"domain_scores_codex":[0.9989879,0.00007755449,0.0001875089,0.0002976849,0.0001635094,0.0002858682],"domain_scores_gemma":[0.999408,0.000009015835,0.00006625641,0.0003255829,0.0001249488,0.00006616824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001476461,0.0002573043,0.001030889,0.00003401888,0.00005691767,0.00002469604,0.0002678728,0.00002502832,0.9919994,0.00003528697,0.0001576721,0.004634403],"study_design_scores_gemma":[0.001245322,0.001785744,0.005555504,0.00003230715,0.00001443948,0.000002784215,0.00007517828,0.0001419394,0.9902185,0.0001051949,0.0006308222,0.0001922458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929049,0.006236483,0.00005244494,0.00002408338,0.0001273706,0.000256924,0.00006108528,0.000009327657,0.0003273793],"genre_scores_gemma":[0.9982354,0.0005361217,0.0005026842,0.0003140959,0.00007704668,0.0000341312,0.00003595705,0.00002797622,0.0002365783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005700362,"threshold_uncertainty_score":0.6264057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466228104683347,"score_gpt":0.3087834715548646,"score_spread":0.2841211905080311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}