{"id":"W1965497380","doi":"10.1038/nature10358","title":"Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":550,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; University of Ottawa; Wilfrid Laurier University; Ottawa Hospital; Western University; Jennerex Biotherapeutics (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Oncolytic virus; Transgene; Cancer; Cancer research; Small interfering RNA; Biology; Cancer cell; Virotherapy; Virus; Systemic administration; Virology; Cell culture; Gene; Transfection; In vivo; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005032128,0.0002812076,0.0003143157,0.0002500894,0.0002501713,0.0005813296,0.000328156,0.000636519,0.0007025787],"category_scores_gemma":[0.0002444861,0.0001559907,0.0002389863,0.0001261226,0.0006145212,0.0006058848,0.0002331203,0.0006861855,0.0002349386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004428489,"about_ca_system_score_gemma":0.000303598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005986168,"about_ca_topic_score_gemma":0.0002808617,"domain_scores_codex":[0.999832,0.00003086766,0.000007074311,0.0000612624,0.0000246384,0.00004415512],"domain_scores_gemma":[0.99992,0.00001819,0.00002265048,0.00002195611,0.000005043258,0.0000121348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.001343452,0.0005407603,0.0006879653,0.0001085181,0.00003617308,0.0004415462,0.0001578298,0.0006954616,0.9630788,0.003142331,0.0008819919,0.02888515],"study_design_scores_gemma":[0.0004649428,0.01220568,0.003428468,0.00004472068,0.00013903,0.002386971,0.0001064736,0.005487314,0.9533574,0.001267913,0.02108745,0.0000236317],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690452,0.002685629,0.0231825,0.0003884351,0.0001432661,0.0002254363,0.0003354557,0.000377759,0.003616429],"genre_scores_gemma":[0.9901187,0.0009620792,0.005434726,0.0001123231,0.00002933091,0.00009886174,0.0002385322,0.00003590345,0.002969459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007025787,"threshold_uncertainty_score":0.003213108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466228104683347,"score_gpt":0.3087834715548646,"score_spread":0.2841211905080311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}