{"id":"W1965503064","doi":"10.1097/gim.0b013e31820c056e","title":"A grand challenge: Providing benefits of clinical genetics to those in need","year":2011,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; CHDI Foundation","keywords":"Risk analysis (engineering); Genetic testing; Disease; Computer science; Business; Medicine; Data science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01838852,0.001188192,0.002149379,0.001826838,0.006906029,0.009694829,0.00323037,0.02636175,0.03583974],"category_scores_gemma":[0.06169543,0.0007736879,0.001515944,0.0008602394,0.01091059,0.0158798,0.01304153,0.02823625,0.01404365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003523574,"about_ca_system_score_gemma":0.01843624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003461722,"about_ca_topic_score_gemma":0.005971957,"domain_scores_codex":[0.9916413,0.003711198,0.0004877886,0.0007323606,0.00222844,0.001199035],"domain_scores_gemma":[0.9293706,0.02431379,0.002159747,0.003324975,0.01125016,0.0295808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001776071,0.0003494448,0.00369184,0.0003402616,0.0001309221,0.002154982,0.0008280718,0.0003925101,0.0007591535,0.03167368,0.852266,0.1072355],"study_design_scores_gemma":[0.0002965608,0.0003179167,0.004999317,0.001910176,0.0001715886,0.007306855,0.00482396,0.0006934218,0.0003558621,0.2325288,0.7463139,0.0002816085],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007267243,0.008718555,0.002434515,0.9761712,0.006589692,0.0000170111,0.00003304453,0.0001420943,0.005167164],"genre_scores_gemma":[0.04320448,0.03143105,0.01924317,0.826617,0.06166083,0.0002154202,0.000204386,0.0003027147,0.01712096],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03583974,"threshold_uncertainty_score":0.1198959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1253019413715959,"score_gpt":0.3921501163567946,"score_spread":0.2668481749851987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}