{"id":"W1965566569","doi":"10.3109/13880209.2010.517540","title":"Depsides isolated from the Sri Lankan lichen<i>Parmotrema</i>sp. exhibit selective Plk1 inhibitory activity","year":2011,"lang":"en","type":"article","venue":"Pharmaceutical Biology","topic":"Lichen and fungal ecology","field":"Agricultural and Biological Sciences","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Natural product; Kinase; PLK1; Biochemistry; IC50; Biology; Enzyme; Chemistry; In vitro; Cell cycle; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003515046,0.0002836573,0.0003512416,0.00001265561,0.0003415416,0.00002542936,0.0005014206,0.0004111927,0.002324567],"category_scores_gemma":[0.0001641959,0.00009935393,0.000155315,0.0003210396,0.0004677306,0.0001110606,0.0002602203,0.0007202995,0.0004150491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004612063,"about_ca_system_score_gemma":0.00002403252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001588668,"about_ca_topic_score_gemma":0.0008100116,"domain_scores_codex":[0.9976892,0.0006445789,0.000275905,0.0005977104,0.0001121761,0.0006804579],"domain_scores_gemma":[0.9981541,0.001289749,0.0001114292,0.0001139039,0.00009186666,0.0002389693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005268287,0.0003639122,0.1541474,0.000002652067,0.0001460294,0.00001346854,0.0005578613,1.303883e-7,0.8024335,0.001457024,0.001675647,0.03867554],"study_design_scores_gemma":[0.0007801591,0.0009994493,0.6393148,0.00001084279,0.0001506101,0.00002888739,0.0003159015,0.0003162246,0.2545474,0.005597567,0.09728532,0.0006528592],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834216,0.0006125154,0.00001297453,0.002821506,0.0004934362,0.0003413157,0.0001014487,0.000186941,0.01200822],"genre_scores_gemma":[0.9947052,0.0001160992,0.00005905826,0.004262518,0.0007127978,0.00004421115,0.00005216007,0.000001780086,0.00004619819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5478861,"threshold_uncertainty_score":0.9985874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07962187721761041,"score_gpt":0.2826633354833452,"score_spread":0.2030414582657347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}