{"id":"W1965611801","doi":"10.1016/j.vaccine.2010.02.081","title":"The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant","year":2010,"lang":"en","type":"review","venue":"Vaccine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University; National Research Council Canada; Institute for Biological Sciences","funders":"National Research Council Canada","keywords":"Adjuvant; Biofilm; Intracellular; Virulence; Vaccine adjuvant; In vivo; Microbiology; In vitro; Cell; Biology; Chemistry; Bacteria; Immunology; Cell biology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008711448,0.0006237807,0.001947471,0.0003105053,0.0004105638,0.00003574339,0.0008537685,0.001147295,0.000460726],"category_scores_gemma":[0.0003779325,0.0003696851,0.0006555049,0.0003419818,0.00004505965,0.0001747299,0.0002315497,0.00133365,0.001316213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005909901,"about_ca_system_score_gemma":0.0001994808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008137968,"about_ca_topic_score_gemma":0.00005137052,"domain_scores_codex":[0.9965059,0.001187681,0.001144616,0.0005201343,0.00007887202,0.0005628599],"domain_scores_gemma":[0.9970473,0.0005224426,0.0009783308,0.001228809,0.0001813991,0.00004171778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004579006,0.00010664,0.000003059053,0.00076571,0.0005593218,0.00001142564,0.00005064639,1.903099e-7,0.03329972,0.0002468517,0.0004028556,0.9640957],"study_design_scores_gemma":[0.001445443,0.0007687105,0.0005134795,0.001305362,0.001095481,0.0005507959,0.00003007539,0.000001481798,0.01367257,0.00009835553,0.9801198,0.0003983952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01219155,0.9837478,0.00002755275,0.0000866948,0.001971623,0.00162674,0.00003440428,0.0000872763,0.0002263729],"genre_scores_gemma":[0.006863361,0.9898075,0.000008611381,0.00002027176,0.0002542681,0.0002257779,0.000869257,0.00008216147,0.001868796],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979717,"threshold_uncertainty_score":0.9998755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007752884704892773,"score_gpt":0.2785141913377139,"score_spread":0.2707613066328212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}