{"id":"W1965619867","doi":"10.1038/ng1221","title":"Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification","year":2003,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Alkaline Phosphatase Research Studies","field":"Medicine","cited_by":603,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's & Women's Health Centre of British Columbia","funders":"Deutsche Forschungsgemeinschaft; Arthritis National Research Foundation; U.S. Department of Veterans Affairs; National Institute for Health and Care Research; Foundation for the National Institutes of Health","keywords":"Calcification; Biology; Phosphodiesterase; Mutation; Pyrophosphate; Pyrophosphatase; Internal elastic lamina; Cell; Internal medicine; Endocrinology; Enzyme; Genetics; Biochemistry; Anatomy; Gene; Medicine; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693301,0.0001249943,0.0002265945,0.0001141202,0.00007239645,0.00001597426,0.00005549593,0.0002344165,0.00001656735],"category_scores_gemma":[0.001419801,0.0001022078,0.00002887608,0.0004980956,0.00008551613,0.00002930412,0.00001665211,0.0005922555,0.00001129126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001108376,"about_ca_system_score_gemma":0.0002036575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005713766,"about_ca_topic_score_gemma":0.0001312977,"domain_scores_codex":[0.9988512,0.00007976057,0.0001945066,0.0002215654,0.0003955532,0.000257388],"domain_scores_gemma":[0.9992169,0.00005328878,0.00009058143,0.000237974,0.0003169383,0.00008436877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006610955,0.001494327,0.9661809,0.0002746704,0.0004624841,0.0006685577,0.002358374,0.0003229349,0.01381546,0.001229946,0.009522202,0.003009012],"study_design_scores_gemma":[0.003206619,0.0002829354,0.9672024,0.0003549494,0.0001052384,0.00003373222,0.0005186345,0.0002741703,0.0200071,0.0004035741,0.007381324,0.0002292888],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891378,0.008509952,0.00009926585,0.0007334172,0.0001399153,0.0004931831,0.00006299307,0.00004149569,0.0007819883],"genre_scores_gemma":[0.9984003,0.000245257,0.0007528555,0.000200726,0.00008854511,0.00003927462,0.000138855,0.00002029649,0.000113942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009262458,"threshold_uncertainty_score":0.4167912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660030137103867,"score_gpt":0.3176670123914281,"score_spread":0.3010667110203894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}