{"id":"W1965637603","doi":"10.1186/1471-2164-9-399","title":"Comparative analysis of function and interaction of transcription factors in nematodes: Extensive conservation of orthology coupled to rapid sequence evolution","year":2008,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Genetics; Gene; Caenorhabditis elegans; Caenorhabditis; Genome; Hox gene; Conserved sequence; Gene family; Comparative genomics; Lineage (genetic); Evolutionary biology; Transcription factor; Genomics; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143241,0.00009414089,0.0003076125,0.0002160477,0.00002318484,0.000001769191,0.00004933622,0.000096661,0.000004504672],"category_scores_gemma":[0.0000374858,0.0001020207,0.0000696096,0.0002146559,0.0001137566,0.000007254259,0.00001771403,0.00004013714,2.186324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003013518,"about_ca_system_score_gemma":0.00006931963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004732738,"about_ca_topic_score_gemma":0.001874329,"domain_scores_codex":[0.9992188,0.00007381666,0.000361511,0.0001950349,0.00006860469,0.00008223247],"domain_scores_gemma":[0.9993305,0.00002218554,0.0002367386,0.0001524573,0.000231474,0.00002663389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002080242,0.00004569179,0.1529868,0.00002879752,0.00009297505,1.01694e-7,0.002588901,0.02523994,0.8187518,0.00003899296,0.00000520876,0.00001287293],"study_design_scores_gemma":[0.0003523213,0.0003680776,0.6535283,0.000008524334,0.0001851208,0.000003256046,0.001830496,0.01198915,0.331593,0.00003867783,0.00001324974,0.00008989921],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9116524,0.0001636947,0.08789854,0.00001037107,0.00006235502,0.0001792247,0.0000236463,0.000002215047,0.000007597816],"genre_scores_gemma":[0.9982362,0.0001547414,0.00141275,0.00002491629,0.000008959382,0.000004246857,0.0001466899,0.000005121678,0.000006316354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5005415,"threshold_uncertainty_score":0.4160283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04943835104337942,"score_gpt":0.2763722481224466,"score_spread":0.2269338970790672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}