{"id":"W1965668388","doi":"10.1021/bi7010288","title":"The Roles of Tyr(CD1) and Trp(G8) in <i>Mycobacterium tuberculosis</i> Truncated Hemoglobin O in Ligand Binding and on the Heme Distal Site Architecture<sup>,</sup>","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Heme; Chemistry; Crystallography; Ligand (biochemistry); Hemoglobin; Resonance Raman spectroscopy; Mutant; Stereochemistry; Hydrogen bond; Crystal structure; Hemeprotein; Wild type; Binding site; Raman spectroscopy; Molecule; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004400459,0.0002240086,0.0001778831,0.00004266718,0.00009994944,0.00003995852,0.0001399188,0.0002338029,0.000002720477],"category_scores_gemma":[0.0001240639,0.0001473789,0.00005611645,0.0001742906,0.0002218505,0.000004198497,0.0001133978,0.0002188581,7.147431e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002715138,"about_ca_system_score_gemma":0.00003542908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000251551,"about_ca_topic_score_gemma":0.000136031,"domain_scores_codex":[0.9987947,0.00004149917,0.0003206592,0.0003805724,0.0001404584,0.0003221277],"domain_scores_gemma":[0.9994,0.00008589019,0.00009108934,0.0003194674,0.00002946526,0.00007409415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004152841,0.00003268397,0.01523505,0.00004755455,0.00002423627,0.000004860507,0.0001989435,0.00001622267,0.9802186,0.00001592254,0.0001729683,0.003617651],"study_design_scores_gemma":[0.0006792406,0.00009205927,0.009550706,0.00006259074,0.00001332567,0.00004667968,0.0005123304,0.00005555982,0.9862306,0.00004055818,0.002528936,0.0001874868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975345,0.001410042,0.00001894866,0.0003573471,0.00004449376,0.0001749534,0.00004912424,0.000007202474,0.0004034392],"genre_scores_gemma":[0.9990935,0.0003769794,0.00003039638,0.0001365677,0.0001335061,0.000009969082,0.0001046693,0.00001737509,0.00009708366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006011907,"threshold_uncertainty_score":0.6009938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003985008337065471,"score_gpt":0.2053889596499854,"score_spread":0.2014039513129199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}