{"id":"W1965668388","doi":"10.1021/bi7010288","title":"The Roles of Tyr(CD1) and Trp(G8) in <i>Mycobacterium tuberculosis</i> Truncated Hemoglobin O in Ligand Binding and on the Heme Distal Site Architecture<sup>,</sup>","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Heme; Chemistry; Crystallography; Ligand (biochemistry); Hemoglobin; Resonance Raman spectroscopy; Mutant; Stereochemistry; Hydrogen bond; Crystal structure; Hemeprotein; Wild type; Binding site; Raman spectroscopy; Molecule; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082824,0.0002926524,0.0001424171,0.00006927163,0.0001162024,0.0001697013,0.000263787,0.0004195821,0.0003725256],"category_scores_gemma":[0.0001560798,0.0001091776,0.0001594136,0.00007091999,0.0003231699,0.0002159696,0.000153662,0.0003796488,0.0001467913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036001,"about_ca_system_score_gemma":0.0001000546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007036653,"about_ca_topic_score_gemma":0.0007648067,"domain_scores_codex":[0.9999343,0.00001338756,0.000006036525,0.00001714144,0.00001482689,0.00001430095],"domain_scores_gemma":[0.9998802,0.00002665272,0.00005472457,0.000009315761,0.000008452073,0.00002059029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003374725,0.00002287277,0.001561615,0.00002922455,0.000005336402,0.0001957385,0.00003175524,0.0002115869,0.9961772,0.0001500928,0.00002939349,0.001247728],"study_design_scores_gemma":[0.00002836403,0.0001614888,0.01330838,0.000007021781,0.00001821042,0.0005127581,0.00006744669,0.002364623,0.9825723,0.00008564141,0.0008637326,0.00001006372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992129,0.0002017174,0.0003672651,0.00003363364,0.000004370158,0.00000284964,0.00002872621,0.000007220471,0.0001413723],"genre_scores_gemma":[0.9990866,0.00009943793,0.00057836,0.00002645617,0.000001811757,0.000004266488,0.00004877477,0.000004166065,0.0001500308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007036653,"threshold_uncertainty_score":0.001477182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003985008337065471,"score_gpt":0.2053889596499854,"score_spread":0.2014039513129199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}