{"id":"W1965674737","doi":"10.1371/journal.pone.0001565","title":"Reproducible, Ultra High-Throughput Formation of Multicellular Organization from Single Cell Suspension-Derived Human Embryonic Stem Cell Aggregates","year":2008,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":409,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Stem Cell Network","keywords":"Embryonic stem cell; Embryoid body; Germ layer; Cell biology; Regenerative medicine; Multicellular organism; Epiblast; Morphogenesis; Biology; Stem cell; Nanotechnology; Embryogenesis; Cell; Materials science; Embryo; Induced pluripotent stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005773847,0.0003525888,0.0002961807,0.0003878264,0.0002274522,0.0005210551,0.0003350638,0.0003156529,0.0005619397],"category_scores_gemma":[0.0004085882,0.0002184915,0.0003139455,0.0002368436,0.0002204834,0.0002693235,0.0004837677,0.0004816589,0.0004984748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002802962,"about_ca_system_score_gemma":0.000198291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002445935,"about_ca_topic_score_gemma":0.000684174,"domain_scores_codex":[0.9996921,0.00004172482,0.00004292541,0.00007552852,0.0001212445,0.00002660774],"domain_scores_gemma":[0.9996709,0.0001115039,0.00005459198,0.00006661211,0.00006819125,0.00002831708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001505464,0.00001507275,0.0001889302,0.00002545032,0.000005783304,0.00002718436,0.00002581854,0.0003726913,0.9962193,0.00006559849,0.00009849133,0.00294053],"study_design_scores_gemma":[0.000005436331,0.0000701601,0.001198686,0.000003329596,0.000009866406,0.00006970419,0.00001094047,0.002818701,0.9945826,0.00004068001,0.001186404,0.00000347284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7110062,0.002176562,0.2782859,0.0002220069,0.00009122528,0.0006295225,0.001817127,0.001828264,0.003943233],"genre_scores_gemma":[0.8489922,0.001288962,0.1447757,0.00007541189,0.00002732103,0.0004090191,0.001798191,0.0001446236,0.002488503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005773847,"threshold_uncertainty_score":0.003053546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03536008210969776,"score_gpt":0.2163318959746378,"score_spread":0.18097181386494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}