{"id":"W1965687988","doi":"10.1021/jf902156k","title":"Synthesis, Biological Activity, and Hologram Quantitative Structure−Activity Relationships of Novel Allatostatin Analogues","year":2009,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pentapeptide repeat; Juvenile hormone; In vitro; In vivo; Biological activity; Stereochemistry; Linker; Chemistry; Structure–activity relationship; Biochemistry; Biology; Combinatorial chemistry; Pharmacology; Hormone; Biotechnology; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067352,0.0001357717,0.0002237735,0.00001489806,0.00006894443,0.00001740658,0.00008020704,0.0001883739,0.000002040951],"category_scores_gemma":[0.0001530538,0.00008285637,0.00007485566,0.00006539627,0.0001134636,0.00001014255,0.00002952022,0.0001935287,3.308352e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006548109,"about_ca_system_score_gemma":0.00002137104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001695929,"about_ca_topic_score_gemma":0.000009191671,"domain_scores_codex":[0.9993949,0.00003845505,0.0001982447,0.0001466541,0.0001009093,0.0001208273],"domain_scores_gemma":[0.9993476,0.00005160138,0.000307525,0.00006845484,0.000151732,0.00007303098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284802,0.00009355734,0.002915042,0.00002307823,0.00007789112,8.116047e-7,0.00005263745,0.00001892093,0.9956767,0.0000241708,0.00006253875,0.0009262048],"study_design_scores_gemma":[0.0002169974,0.0006124332,0.3998622,0.00002048007,0.00002631961,0.0001270022,0.000179225,0.000002052484,0.5987591,0.00008056444,0.00002676461,0.00008691098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998027,0.00146186,0.0001019256,0.0002036579,0.00001702546,0.00004132124,0.00005386968,0.000002303484,0.00009107246],"genre_scores_gemma":[0.9976788,0.0006001858,0.001585389,0.00001492395,0.0000906797,5.17244e-7,0.00001117678,0.000002732834,0.00001559613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3969471,"threshold_uncertainty_score":0.3378785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02634162539631117,"score_gpt":0.2531279664140968,"score_spread":0.2267863410177856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}