{"id":"W1965687988","doi":"10.1021/jf902156k","title":"Synthesis, Biological Activity, and Hologram Quantitative Structure−Activity Relationships of Novel Allatostatin Analogues","year":2009,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pentapeptide repeat; Juvenile hormone; In vitro; In vivo; Biological activity; Stereochemistry; Linker; Chemistry; Structure–activity relationship; Biochemistry; Biology; Combinatorial chemistry; Pharmacology; Hormone; Biotechnology; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626951,0.0003886016,0.0003789999,0.0001531097,0.0000805044,0.000198322,0.0002570368,0.0001516293,0.0007992953],"category_scores_gemma":[0.00022134,0.0001264971,0.0004262318,0.0002492432,0.0001405775,0.0002427919,0.0001558335,0.0005691238,0.00020112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966127,"about_ca_system_score_gemma":0.0002373608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008488063,"about_ca_topic_score_gemma":0.001258998,"domain_scores_codex":[0.9999104,0.00001257893,0.00001085489,0.00002549089,0.00002396907,0.00001678455],"domain_scores_gemma":[0.9999057,0.00001347453,0.00003439215,0.000009385716,0.00001826193,0.0000186882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004512249,0.000168679,0.0008313191,0.0002396241,0.00005714698,0.0001138757,0.00003787071,0.01189799,0.967631,0.0002517214,0.0002366303,0.01808284],"study_design_scores_gemma":[0.0002390816,0.004837749,0.009760381,0.00001774686,0.0001897998,0.0005207363,0.00008090327,0.04062765,0.9378325,0.0002307964,0.005611312,0.00005134058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845707,0.003037445,0.009940686,0.00006149063,0.00002092702,0.00008388757,0.0007133705,0.00009925499,0.001472327],"genre_scores_gemma":[0.9865311,0.002327202,0.007748357,0.00007014263,0.000007754576,0.00007405275,0.001499658,0.00002029165,0.001721484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008488063,"threshold_uncertainty_score":0.002673924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02634162539631117,"score_gpt":0.2531279664140968,"score_spread":0.2267863410177856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}