{"id":"W1965705756","doi":"10.1016/s0006-2952(00)00252-5","title":"Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions","year":2000,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Tumor necrosis factor alpha; Respiratory burst; Peripheral blood mononuclear cell; Receptor; Secretion; Phagocyte; Mononuclear phagocyte system; Inflammation; Biology; Proinflammatory cytokine; Glutamate receptor; Chemistry; Pharmacology; Molecular biology; Immunology; Biochemistry; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003053713,0.0004022408,0.0004756941,0.0003782777,0.0003293073,0.0000309805,0.0008188704,0.000282016,0.002550374],"category_scores_gemma":[0.0002343047,0.0003884622,0.0002413574,0.0008383257,0.001471357,0.0003445417,0.0002619463,0.001207692,0.001003179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001194765,"about_ca_system_score_gemma":0.0001532411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001342864,"about_ca_topic_score_gemma":8.434609e-8,"domain_scores_codex":[0.9958767,0.0006749871,0.0006259378,0.001262761,0.0006142732,0.0009453667],"domain_scores_gemma":[0.9982016,0.0006928985,0.0001855087,0.0004311781,0.00007993602,0.0004088919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001717142,0.001110389,0.00001080888,0.00003474623,0.00001560517,0.0000910918,0.0000394296,0.000283079,0.9715195,0.0001226805,0.0217996,0.003255899],"study_design_scores_gemma":[0.001785221,0.00100594,0.0001247386,0.0000100885,0.00005662476,0.000042477,0.00001291296,0.001032501,0.9878345,0.0004121876,0.007364751,0.000318019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946186,0.0001779427,0.000006363623,0.001284618,0.001804402,0.0006206355,0.00004794704,0.0002491015,0.001190395],"genre_scores_gemma":[0.9906088,0.0009620585,0.00002920847,0.006175758,0.0006099167,0.0001101258,0.000002583664,0.00006167137,0.001439909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01631501,"threshold_uncertainty_score":0.9998567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06504323009714212,"score_gpt":0.3579931354046439,"score_spread":0.2929499053075018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}