{"id":"W1965717563","doi":"10.1002/cpt.59","title":"From adaptive licensing to adaptive pathways: Delivering a flexible life‐span approach to bring new drugs to patients","year":2015,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National d'Excellence en Santé et en Services Sociaux; Canadian Agency for Drugs and Technologies in Health; Health Canada","funders":"European Federation of Pharmaceutical Industries and Associations","keywords":"Risk analysis (engineering); Sustainability; Business; Drug development; Life span; Adaptive strategies; New product development; Medicine; Drug; Marketing; Gerontology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02105971,0.0007670069,0.0006700698,0.001455033,0.001323227,0.006310981,0.002058311,0.005166028,0.01614911],"category_scores_gemma":[0.04929308,0.0004394852,0.00145379,0.0007984156,0.007620467,0.01657066,0.008633748,0.006779435,0.001556286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004099244,"about_ca_system_score_gemma":0.006568216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007829182,"about_ca_topic_score_gemma":0.0008127998,"domain_scores_codex":[0.9867991,0.008778818,0.0004191822,0.001226298,0.001742771,0.001033901],"domain_scores_gemma":[0.9734402,0.01553386,0.002891218,0.002528454,0.00142332,0.004183026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003187791,0.0003727161,0.003008608,0.0004611564,0.0001634509,0.0002579952,0.0007298143,0.01007007,0.001111584,0.8369172,0.008350499,0.1382382],"study_design_scores_gemma":[0.0001356322,0.0004041045,0.001017702,0.0003071214,0.00003477005,0.0002431614,0.0002355992,0.00652278,0.0006109374,0.957428,0.03300295,0.00005720193],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05563411,0.01125314,0.5151953,0.2670037,0.001846548,0.0009568985,0.0003632067,0.0006388974,0.1471083],"genre_scores_gemma":[0.8795105,0.004361512,0.07607004,0.02714549,0.001680963,0.0008066738,0.0000970386,0.0001734778,0.01015429],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02105971,"threshold_uncertainty_score":0.1113757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.696669527203476,"score_gpt":0.5022952081605061,"score_spread":0.1943743190429699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}