{"id":"W1965717566","doi":"10.1002/ajmg.a.37089","title":"The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach","year":2015,"lang":"en","type":"article","venue":"American Journal of Medical Genetics Part A","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Children's Hospital of Eastern Ontario","funders":"National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Plexxikon; National Institute of General Medical Sciences; National Institute of Mental Health; Children's Tumor Foundation; Novo Nordisk; Wellcome Trust; National Cancer Institute; March of Dimes Foundation","keywords":"Noonan syndrome; MAPK/ERK pathway; Medicine; Theme (computing); Therapeutic approach; Identification (biology); Panel discussion; Critical pathways; Psychiatry; Kinase; Internal medicine; Biology; Genetics; Disease; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00379124,0.001058057,0.0004326274,0.0007135104,0.0009858058,0.002694725,0.0009219517,0.004305647,0.01334396],"category_scores_gemma":[0.001888257,0.0002274785,0.001115183,0.0002652579,0.0008161643,0.001394103,0.001818725,0.005770926,0.004949728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002306727,"about_ca_system_score_gemma":0.003467687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285946,"about_ca_topic_score_gemma":0.003658714,"domain_scores_codex":[0.998808,0.0004118006,0.00006814598,0.0001220919,0.0003542076,0.0002357499],"domain_scores_gemma":[0.9988629,0.0001111325,0.00006084476,0.00002183666,0.0003429815,0.0006003816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002521334,0.00008023401,0.0004444941,0.0002644014,0.00002450392,0.0004247841,0.000206396,0.000131195,0.003514533,0.004989966,0.9242915,0.06537587],"study_design_scores_gemma":[0.00003148993,0.0000779309,0.0006598509,0.0002364567,0.00002117403,0.000475005,0.0001559615,0.00008799631,0.0009908421,0.001299685,0.9959496,0.00001385817],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.006711164,0.1068178,0.009319369,0.4906597,0.3084902,0.0003522087,0.000485219,0.0002659156,0.07689834],"genre_scores_gemma":[0.06656561,0.1243136,0.01627017,0.1326445,0.1235808,0.0007784032,0.0009976091,0.0003425139,0.5345069],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01334396,"threshold_uncertainty_score":0.04464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806578461738078,"score_gpt":0.2864944336250053,"score_spread":0.2684286490076245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}