{"id":"W1965799368","doi":"10.1074/jbc.r114.609248","title":"Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter","year":2014,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":367,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"ABCC1; ATP-binding cassette transporter; Efflux; Transporter; Multiple drug resistance; Leukotriene C4; Multidrug Resistance-Associated Proteins; Biology; Abcg2; P-glycoprotein; Human multitasking; Cell biology; Biochemistry; Chemistry; Drug resistance; Microbiology; Gene; Leukotriene; Immunology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0009933709,0.0008155919,0.003980496,0.0001229794,0.000121742,0.00003770776,0.0005827458,0.001328796,0.0003787015],"category_scores_gemma":[0.0001832712,0.0004809928,0.002226755,0.0002974856,0.0002311005,0.0000681549,0.0000285297,0.002080898,0.00002950135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002809194,"about_ca_system_score_gemma":0.0003839274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001024994,"about_ca_topic_score_gemma":0.000001321068,"domain_scores_codex":[0.9957575,0.00009394823,0.002232489,0.0006168514,0.000658182,0.0006410204],"domain_scores_gemma":[0.9966541,0.0001524819,0.001937987,0.0005082336,0.0002418669,0.000505363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003538763,0.003167699,0.0004151775,0.3558715,0.005800195,0.02816785,0.000578516,0.000001854228,0.1790993,0.0001277552,0.005183112,0.4180483],"study_design_scores_gemma":[0.001133438,0.0001371133,0.00001999444,0.04140443,0.001252711,0.0007669274,0.00003497242,8.908632e-7,0.004777799,0.00003099483,0.949878,0.0005627162],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006493362,0.9900785,0.0004005505,0.000223058,0.000277921,0.0007900153,0.0001209527,0.00006886137,0.001546754],"genre_scores_gemma":[0.004965888,0.9833571,0.004093527,0.00008948812,0.001495807,0.00005076904,0.0002353937,0.0001006867,0.005611348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9446949,"threshold_uncertainty_score":0.9999677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04616766677798811,"score_gpt":0.3121300085508663,"score_spread":0.2659623417728782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}