{"id":"W1965799368","doi":"10.1074/jbc.r114.609248","title":"Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter","year":2014,"lang":"en","type":"review","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":367,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"ABCC1; ATP-binding cassette transporter; Efflux; Transporter; Multiple drug resistance; Leukotriene C4; Multidrug Resistance-Associated Proteins; Biology; Abcg2; P-glycoprotein; Human multitasking; Cell biology; Biochemistry; Chemistry; Drug resistance; Microbiology; Gene; Leukotriene; Immunology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436325,0.0007577722,0.001265277,0.001967609,0.0002773741,0.0009018093,0.0006778305,0.0008125358,0.003240826],"category_scores_gemma":[0.0004061456,0.0002168823,0.0003527087,0.002263022,0.0004232309,0.001114019,0.0005408337,0.00135177,0.003277723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005544939,"about_ca_system_score_gemma":0.0007469919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006321321,"about_ca_topic_score_gemma":0.001090654,"domain_scores_codex":[0.9998788,0.00001774656,0.00001476918,0.00002474646,0.00004889601,0.0000151057],"domain_scores_gemma":[0.9998224,0.00005349734,0.00002976264,0.000006208745,0.00006290826,0.00002509977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005420329,0.00006023694,0.0002148631,0.01098263,0.00007045972,0.0002293058,0.00004199673,0.000279391,0.003757997,0.004400177,0.03307961,0.9468291],"study_design_scores_gemma":[0.000009131782,0.00005726643,0.0005736789,0.0008365703,0.00005761396,0.001275969,0.00003076004,0.00006036169,0.0007045525,0.001201064,0.9951792,0.00001396772],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002030734,0.9977857,0.0002258432,0.0003111033,0.0001537077,0.000005759447,0.00003047971,0.00001436625,0.001270009],"genre_scores_gemma":[0.0009608494,0.9975246,0.0002692011,0.0001273325,0.00009854573,0.000006910852,0.00005383488,0.000001777721,0.0009569665],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003240826,"threshold_uncertainty_score":0.01084161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04616766677798811,"score_gpt":0.3121300085508663,"score_spread":0.2659623417728782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}