{"id":"W1965870838","doi":"10.1213/01.ane.0000281046.77228.91","title":"Propofol Reduces Apoptosis and Up-Regulates Endothelial Nitric Oxide Synthase Protein Expression in Hydrogen Peroxide-Stimulated Human Umbilical Vein Endothelial Cells","year":2007,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Umbilical vein; Medicine; Enos; Viability assay; Protein kinase B; Oxidative stress; Apoptosis; Endothelial stem cell; Nitric oxide; Nitric oxide synthase; Pharmacology; Molecular biology; Biochemistry; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131435,0.0003258304,0.0002662544,0.0001630264,0.0001145237,0.0001731727,0.0001305103,0.0001854822,0.0009760718],"category_scores_gemma":[0.0001566437,0.0001007634,0.0003382263,0.0001647561,0.0001098686,0.0001977516,0.0001377729,0.0005411862,0.0001744799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001297087,"about_ca_system_score_gemma":0.000194778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004290268,"about_ca_topic_score_gemma":0.0004723273,"domain_scores_codex":[0.9998697,0.00002756825,0.00001963433,0.00001278624,0.00003495182,0.00003531522],"domain_scores_gemma":[0.9999152,0.00001200504,0.00003005816,0.000008947752,0.00001836629,0.00001534373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002029314,0.0005959536,0.001398145,0.0003640333,0.00005504636,0.0002518833,0.00006525275,0.0001792729,0.9813946,0.0001025773,0.0004587098,0.0131052],"study_design_scores_gemma":[0.0001799696,0.003391966,0.01776597,0.00002564871,0.0001196408,0.000580639,0.0001147057,0.001650005,0.9722179,0.00008707136,0.003855755,0.00001079087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890164,0.007154595,0.002167469,0.000170562,0.0001207587,0.00003289759,0.0001969499,0.0000559138,0.001084403],"genre_scores_gemma":[0.9927679,0.00428512,0.0009934672,0.00009996632,0.00003054639,0.0000481905,0.000460781,0.000005648235,0.001308346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009760718,"threshold_uncertainty_score":0.003265321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592119678484785,"score_gpt":0.2849176640724246,"score_spread":0.2589964672875767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}