{"id":"W1965872755","doi":"10.1002/bit.10128","title":"Low‐protein medium affects the 293SF central metabolism during growth and infection with adenovirus","year":2001,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Polytechnique Montréal","funders":"","keywords":"Glutamine; Citric acid cycle; Metabolic flux analysis; Amino acid; Glycolysis; Metabolism; Protein biosynthesis; Biochemistry; Pentose phosphate pathway; Biology; Flux (metallurgy); Cell culture; Recombinant DNA; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001372667,0.0002719782,0.0003048565,0.0001655089,0.0001706777,0.0005211045,0.0001954001,0.0001908274,0.0005661826],"category_scores_gemma":[0.0001473851,0.000123183,0.0002239043,0.0001330707,0.000170379,0.0002285498,0.0002065814,0.0005270025,0.0002349603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003770076,"about_ca_system_score_gemma":0.0001638891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085015,"about_ca_topic_score_gemma":0.0009770882,"domain_scores_codex":[0.9998447,0.00002815128,0.00001267194,0.00003322509,0.00005214986,0.00002911912],"domain_scores_gemma":[0.9998862,0.0000348504,0.00002543908,0.00001485594,0.0000159982,0.00002279868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009009803,0.00001266069,0.0001509051,0.00001073785,0.000001982354,0.00001586108,0.00001180285,0.00003902753,0.9992014,0.00003899997,0.00000904438,0.0004174938],"study_design_scores_gemma":[0.000004599227,0.0001207827,0.00275618,0.000002464363,0.000007973968,0.00009115024,0.00002348129,0.001084429,0.9951206,0.00003841096,0.0007448205,0.000005096574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945779,0.0007149076,0.003483827,0.00004429941,0.00001753028,0.00001376266,0.000406018,0.00005033885,0.000691419],"genre_scores_gemma":[0.9922828,0.0004638594,0.004367618,0.00003141978,0.000005678277,0.00002503768,0.001093597,0.00006196496,0.001667952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085015,"threshold_uncertainty_score":0.002735436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003048754708961173,"score_gpt":0.1863421621050278,"score_spread":0.1832934073960666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}