{"id":"W1965878646","doi":"10.1371/journal.pntd.0001849","title":"Leishmania donovani Argininosuccinate Synthase Is an Active Enzyme Associated with Parasite Pathogenesis","year":2012,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Leishmania donovani; Argininosuccinate synthase; Leishmaniasis; Pathogenesis; Leishmania; Biology; Neglected tropical diseases; Enzyme; Parasite hosting; Leishmania mexicana; Microbiology; Arginase; Virology; Immunology; Medicine; Visceral leishmaniasis; Biochemistry; Pathology; Arginine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000003597879,0.000275034,0.0002438837,0.00005692595,0.0001602372,0.0000493975,0.0001757019,0.0001236015,0.000208247],"category_scores_gemma":[0.0001860883,0.0002214241,0.0001083169,0.0002182212,0.0001005562,0.00003037261,0.00006863376,0.0001075389,0.00003261032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007912319,"about_ca_system_score_gemma":0.000129565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005900786,"about_ca_topic_score_gemma":0.0001747833,"domain_scores_codex":[0.9982163,0.0001705942,0.0001537963,0.0004604523,0.0003172543,0.0006815716],"domain_scores_gemma":[0.9986778,0.0000352399,0.00007676378,0.0003904415,0.0001512343,0.0006684881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002939847,0.005201136,0.3718377,0.00003098965,0.001481328,0.00009495953,0.00009299815,0.000004413819,0.6133881,0.00003089819,0.001122155,0.003775433],"study_design_scores_gemma":[0.001422305,0.0009674003,0.8312954,0.00002821987,0.0002286351,0.000005417625,0.00002149331,0.00002475814,0.1652787,0.00001551439,0.0004528704,0.0002592453],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969427,0.001371025,0.00006431918,0.00007119835,0.00003109518,0.0003206907,0.001017793,0.00006328268,0.0001178945],"genre_scores_gemma":[0.997898,0.0001561941,0.00006143162,0.0002522396,0.0002284951,0.0001571311,0.001080191,0.00004828021,0.0001180703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4594577,"threshold_uncertainty_score":0.9029411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796202084570121,"score_gpt":0.2665777984829275,"score_spread":0.2486157776372263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}