{"id":"W1965878646","doi":"10.1371/journal.pntd.0001849","title":"Leishmania donovani Argininosuccinate Synthase Is an Active Enzyme Associated with Parasite Pathogenesis","year":2012,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; U.S. Food and Drug Administration; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Leishmania donovani; Argininosuccinate synthase; Leishmaniasis; Pathogenesis; Leishmania; Biology; Neglected tropical diseases; Enzyme; Parasite hosting; Leishmania mexicana; Microbiology; Arginase; Virology; Immunology; Medicine; Visceral leishmaniasis; Biochemistry; Pathology; Arginine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008892366,0.000383585,0.0001555273,0.0001774415,0.0001160159,0.000222161,0.0001261366,0.000198031,0.0007455386],"category_scores_gemma":[0.00008153448,0.00009306896,0.0001634557,0.0001294711,0.0002118712,0.0001165569,0.0001917909,0.0002313641,0.0003378153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002741819,"about_ca_system_score_gemma":0.0001611656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003182713,"about_ca_topic_score_gemma":0.0003760418,"domain_scores_codex":[0.9999317,0.0000117572,0.00000504324,0.00001930525,0.00001623568,0.00001600624],"domain_scores_gemma":[0.9999393,0.000007276381,0.00002021431,0.000006581039,0.00001135643,0.00001523291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005513766,0.000008870425,0.0007301684,0.00007156299,0.000004372015,0.00006926848,0.000008775379,0.00002341063,0.997786,0.0001045685,0.00003016464,0.001107521],"study_design_scores_gemma":[0.00002141693,0.0002563096,0.02150128,0.0000152899,0.00003156791,0.001815566,0.0000643439,0.0007663117,0.963519,0.0002049843,0.01179842,0.000005536694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989618,0.003093717,0.005178602,0.0001533216,0.00003278564,0.00003342587,0.0003903078,0.0001025539,0.001397208],"genre_scores_gemma":[0.993983,0.0008885926,0.002238466,0.00004244331,0.00001148364,0.00002218019,0.001039457,0.00001220119,0.001762076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007455386,"threshold_uncertainty_score":0.002494037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01796202084570121,"score_gpt":0.2665777984829275,"score_spread":0.2486157776372263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}