{"id":"W1965888676","doi":"10.1038/ng.3065","title":"Human somatic cell mutagenesis creates genetically tractable sarcomas","year":2014,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Biology; Insertional mutagenesis; Transposable element; Somatic cell; Genetics; Germline; Mutagenesis; Gene; Genome; Computational biology; Retrotransposon; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283898,0.0004001676,0.0002321906,0.0004865646,0.0001416951,0.0003079506,0.0002515981,0.0003897796,0.002240432],"category_scores_gemma":[0.0002336788,0.00023747,0.0002491019,0.0002354818,0.0003786695,0.0001781033,0.0003029711,0.0005101427,0.0007075436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672789,"about_ca_system_score_gemma":0.0002384221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983651,"about_ca_topic_score_gemma":0.0007015715,"domain_scores_codex":[0.9998112,0.00004528845,0.00001895936,0.00003139715,0.00006148471,0.00003169483],"domain_scores_gemma":[0.9998148,0.00006193141,0.00005082571,0.00003311003,0.00001060523,0.00002873727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005998124,0.00002235047,0.0001431684,0.00001851487,0.000008322589,0.000101589,0.00002104084,0.0003191091,0.9947551,0.002752353,0.00007541457,0.001723006],"study_design_scores_gemma":[0.00002312503,0.0001263417,0.0008066078,0.000005139423,0.00002043827,0.0005916625,0.00002022715,0.001545074,0.9907696,0.0004361388,0.00564975,0.000005900925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599869,0.0008348367,0.03011465,0.000235413,0.0001260803,0.0001629825,0.0009031784,0.0004664721,0.00716956],"genre_scores_gemma":[0.9860036,0.000627819,0.008170904,0.00004463916,0.00001404526,0.00003211107,0.0004131807,0.0000978639,0.004595884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002240432,"threshold_uncertainty_score":0.007494926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008950418987346418,"score_gpt":0.2841832261376065,"score_spread":0.2752328071502601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}