{"id":"W1965899699","doi":"10.1371/journal.ppat.1000291","title":"HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice","year":2009,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Hepatitis C virus research","field":"Medicine","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vernon Jubilee Hospital; University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institute on Drug Abuse; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; Canadian Association for the Study of the Liver","keywords":"Apoptosis; Biology; Unfolded protein response; Oxidative stress; Hepatitis C virus; Hepatocyte; Immunology; Virology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030003,0.000949545,0.0004721356,0.001397844,0.0004206927,0.0004555302,0.0002888413,0.0006861957,0.003276794],"category_scores_gemma":[0.0001553191,0.0005345112,0.0006076547,0.0003531345,0.0005321428,0.0004856426,0.000282515,0.001457405,0.001132258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004175864,"about_ca_system_score_gemma":0.000222992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979719,"about_ca_topic_score_gemma":0.0007853995,"domain_scores_codex":[0.9996796,0.00004431023,0.00004473623,0.00007339776,0.0000761718,0.00008192712],"domain_scores_gemma":[0.9996706,0.00002821723,0.00009993092,0.00005621522,0.00002503592,0.0001199289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008517449,0.000257826,0.0003238915,0.00004505715,0.00001213207,0.0001442467,0.00003489669,0.00007008454,0.9971222,0.0001480995,0.00007292102,0.0009168428],"study_design_scores_gemma":[0.0002520016,0.002539083,0.01541442,0.00003053574,0.00006475387,0.001186354,0.0001011446,0.002619833,0.9740551,0.0002540418,0.00345983,0.00002288861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908133,0.00139656,0.002194272,0.0003131643,0.00008031245,0.00009903918,0.001901828,0.0003047347,0.002896786],"genre_scores_gemma":[0.9806365,0.002028606,0.003190394,0.000301068,0.00005992967,0.0002648673,0.002423916,0.0001297881,0.01096488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003276794,"threshold_uncertainty_score":0.01096195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702380776466781,"score_gpt":0.2921241108385855,"score_spread":0.2651003030739177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}