{"id":"W1965907646","doi":"10.1038/srep01079","title":"Solution structure of the Big domain from Streptococcus pneumoniae reveals a novel Ca2+-binding module","year":2013,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Key Research and Development Program of China; Goddard Space Flight Center","keywords":"Streptococcus pneumoniae; Domain (mathematical analysis); Protein structure; Immunoglobulin domain; Binding domain; Computational biology; Protein domain; Pathogenesis; Pyrin domain; Chemistry; Plasma protein binding; Biology; Binding site; Biophysics; Cell biology; Antibody; Receptor; Biochemistry; Gene; Genetics; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000665168,0.0002108575,0.0001729076,0.0001262792,0.0001332232,0.0001252855,0.0002385817,0.0003150883,0.0005358704],"category_scores_gemma":[0.0001533124,0.00009103076,0.0001700622,0.0001292934,0.0001583954,0.0001529737,0.0001599682,0.0003306933,0.0001074491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001624203,"about_ca_system_score_gemma":0.0001589245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003670365,"about_ca_topic_score_gemma":0.0004012538,"domain_scores_codex":[0.9999717,0.00000528647,0.000001851568,0.000006270203,0.000008000241,0.000006762104],"domain_scores_gemma":[0.9999183,0.00001673439,0.00002338266,0.000004391231,0.00001252059,0.00002461317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003364662,0.000038806,0.002280577,0.00008080733,0.00001872502,0.0003499575,0.00006904366,0.0006589722,0.993518,0.0002317178,0.0001372108,0.00227972],"study_design_scores_gemma":[0.0002403164,0.002150842,0.0900523,0.00006873017,0.0001533409,0.00427617,0.0004940034,0.03437893,0.8510047,0.002346769,0.01472898,0.0001048013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979965,0.0003361836,0.001173493,0.00005941331,0.000007080833,0.000004628213,0.0001001066,0.00001264298,0.0003099653],"genre_scores_gemma":[0.9967077,0.0001390153,0.002342175,0.00005948106,0.000005095626,0.000004145058,0.000480467,0.000003698862,0.0002581609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005358704,"threshold_uncertainty_score":0.001792669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.016291913435802,"score_gpt":0.2446056563995134,"score_spread":0.2283137429637114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}