{"id":"W1965916060","doi":"10.1038/ni.2169","title":"Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus","year":2011,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"National Heart, Lung, and Blood Institute","keywords":"Acquired immune system; Vesicular stomatitis virus; Immune system; Biology; Innate immune system; Viral replication; Virology; Interferon; Antigen presentation; Virus; Antigen; Immunology; Immunity; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003398637,0.0001720864,0.0002856771,0.0001057255,0.0002926751,0.000006712868,0.0002452084,0.0007446143,0.0005128825],"category_scores_gemma":[0.0002821127,0.0001243258,0.0001284137,0.00008434283,0.0004241283,0.0001407625,0.00006573247,0.0009289615,0.00003470679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002902566,"about_ca_system_score_gemma":0.00004088743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004116308,"about_ca_topic_score_gemma":0.00001187991,"domain_scores_codex":[0.9989175,0.0002178189,0.0003241091,0.000280986,0.00002524572,0.000234308],"domain_scores_gemma":[0.9984419,0.0004442639,0.0003191103,0.0005406362,0.0002464615,0.000007647164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004952081,0.00009443184,0.0001042386,0.000008169022,0.0005726421,2.002474e-7,0.001378641,2.737972e-7,0.9766977,0.00875648,0.0007573557,0.006677826],"study_design_scores_gemma":[0.00227126,0.000795581,0.01108182,0.0000156395,0.0001406146,0.00006837701,0.0007847649,0.00005864664,0.9599825,0.0005821931,0.02408112,0.0001375287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.932179,0.0371784,0.01794688,0.0009281845,0.007340604,0.001889956,0.00009717259,0.0001539508,0.002285816],"genre_scores_gemma":[0.9975827,0.0003781394,0.00005803712,0.0005002202,0.0000290982,0.0001005123,0.00005260825,0.00001522358,0.001283413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06540371,"threshold_uncertainty_score":0.5743147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220985719518769,"score_gpt":0.2454583519184257,"score_spread":0.233248494723238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}