{"id":"W1965958936","doi":"10.1016/j.jmb.2008.10.095","title":"Severe Myopathy Mutations Modify the Nanomechanics of Desmin Intermediate Filaments","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Desmin; Intermediate filament; Myofibril; Protein filament; Cytoskeleton; Cell biology; Myopathy; Biophysics; Nanomechanics; Mechanotransduction; Mutant; Chemistry; Intermediate Filament Protein; Biology; Biochemistry; Vimentin; Nanotechnology; Atomic force microscopy; Materials science; Genetics; Immunology; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001611641,0.0005341801,0.0002247993,0.0003008199,0.0002045272,0.0002227347,0.0002092116,0.0004669384,0.001989077],"category_scores_gemma":[0.0003737552,0.0002824689,0.0002384142,0.0001206793,0.000479056,0.0002353801,0.0003656331,0.0005361054,0.0003575814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021287,"about_ca_system_score_gemma":0.0001193992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004554815,"about_ca_topic_score_gemma":0.0008212481,"domain_scores_codex":[0.9998401,0.00003316393,0.0000213983,0.0000355068,0.00004764348,0.0000219918],"domain_scores_gemma":[0.999612,0.00009049138,0.0001515335,0.00004236993,0.00002757669,0.00007608157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112152,0.0000131731,0.0006029985,0.0000241377,0.00001743581,0.0002423471,0.00001865324,0.0002702049,0.9972995,0.0002660614,0.00005801234,0.001075365],"study_design_scores_gemma":[0.00005901253,0.0004577308,0.06203788,0.00001936842,0.00007922366,0.004037553,0.0001226732,0.003830316,0.9261869,0.0009693656,0.002168668,0.00003127975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995829,0.0002726842,0.002858647,0.00007632038,0.0000257017,0.00001079124,0.000145128,0.00006116196,0.0007204235],"genre_scores_gemma":[0.9984358,0.00009847785,0.000726188,0.0000426056,0.000005864696,0.000006976651,0.00007286871,0.00002972003,0.0005815357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001989077,"threshold_uncertainty_score":0.006654084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01572310346132606,"score_gpt":0.2844115993338091,"score_spread":0.268688495872483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}