{"id":"W1965969890","doi":"10.1016/j.febslet.2010.04.047","title":"Defective cholesterol trafficking in Niemann‐Pick C‐deficient cells","year":2010,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"NPC1; Endosome; Neurodegeneration; Cholesterol; Niemann–Pick disease; Niemann–Pick disease, type C; Intracellular; Cell biology; Chemistry; Intracellular transport; Mutation; Biochemistry; Biology; Medicine; Disease; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002498383,0.0006936362,0.001123773,0.00149059,0.0002234988,0.0005330843,0.0005261665,0.0006183328,0.001974223],"category_scores_gemma":[0.0002165114,0.0001880451,0.0002368664,0.001116854,0.0002576913,0.0005776649,0.0003423572,0.0006239105,0.00371682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004127418,"about_ca_system_score_gemma":0.0005164955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007727827,"about_ca_topic_score_gemma":0.001067598,"domain_scores_codex":[0.9999158,0.000009132646,0.00001140097,0.00001421895,0.00004022375,0.000009149644],"domain_scores_gemma":[0.9999332,0.00001627235,0.00001218129,0.00000377933,0.00002179804,0.00001273511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001202052,0.00006012567,0.0002224657,0.007531455,0.00006369174,0.0009657712,0.00006019543,0.0002918495,0.01958312,0.003941845,0.02044457,0.9467147],"study_design_scores_gemma":[0.0000275349,0.00008878074,0.001086107,0.001050921,0.00007019104,0.003539938,0.00004804724,0.00006888491,0.004711481,0.001655074,0.9876366,0.00001643168],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007202585,0.9942821,0.0003885625,0.0001998289,0.0001674779,0.000008782372,0.00003387458,0.00002958747,0.004169535],"genre_scores_gemma":[0.00216092,0.9951432,0.0004186305,0.0001236184,0.00008477818,0.000008585671,0.00005350607,0.000002222268,0.00200457],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001974223,"threshold_uncertainty_score":0.006604433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040081327515293,"score_gpt":0.3407575387610439,"score_spread":0.3006762112457509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}