{"id":"W1965971533","doi":"10.1016/j.ymthe.2006.08.1003","title":"913. Histone Deacetylase Inhibitors Improve Gene Transfer To Mature Skeletal Muscle","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Histone deacetylase; HDAC11; Histone; Gene transfer; HDAC10; Skeletal muscle; Gene; Histone deacetylase 2; Histone deacetylase 5; Cell biology; Chemistry; Biology; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002655675,0.0003762102,0.0002475151,0.0001259765,0.0001274392,0.00005598474,0.0004130416,0.000298586,0.0001013845],"category_scores_gemma":[0.00001186954,0.0003670938,0.000290128,0.0002706296,0.0001013799,0.000005886289,0.00006431005,0.0002269339,0.00009305905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006075903,"about_ca_system_score_gemma":0.0001181667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000918826,"about_ca_topic_score_gemma":0.0001253571,"domain_scores_codex":[0.9977375,0.0001565515,0.0003019611,0.0007401855,0.0004168489,0.0006469045],"domain_scores_gemma":[0.9988012,0.00000645656,0.00002501576,0.0008192015,0.0001314983,0.000216664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000869842,0.0002061269,0.00001279722,0.000007262371,0.00007392651,0.00004855886,0.0000412103,0.0002759651,0.9790964,0.00003441111,0.001751235,0.01758226],"study_design_scores_gemma":[0.001617372,0.00224363,0.0002473952,0.000005329541,0.000008636837,0.00001011755,0.00001059205,0.00001214057,0.9235006,0.00007165158,0.07185378,0.0004187425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877115,0.005688756,0.004365445,0.0007772545,0.0001996768,0.0007184851,0.00005702688,0.00005244296,0.0004293808],"genre_scores_gemma":[0.9947168,0.0002169825,0.0006505509,0.002145837,0.0005173068,0.0001430501,0.0002498331,0.000138051,0.001221654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07010254,"threshold_uncertainty_score":0.9998781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006544874877718977,"score_gpt":0.26294134408648,"score_spread":0.256396469208761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}